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首页> 外文期刊>Acta biomaterialia >Bio-inspired human in vitro outer retinal models: Bruch's membrane and its cellular interactions
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Bio-inspired human in vitro outer retinal models: Bruch's membrane and its cellular interactions

机译：生物启发的人体外外视网膜模型：Bruch的膜及其细胞相互作用

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摘要

Retinal degenerative disorders, such as age-related macular degeneration (AMD), are one of the leading causes of blindness worldwide, however, treatments to completely stop the progression of these debilitating conditions are non-existent. Researchers require sophisticated models that can accurately represent the native structure of human retinal tissue to study these disorders. Current in vitro models used to study the retina are limited in their ability to fully recapitulate the structure and function of the retina, Bruch's membrane and the underlying choroid. Recent developments in the field of induced pluripotent stem cell technology has demonstrated the capability of retinal pigment epithelial cells to recapitulate AMD-like pathology. However, such studies utilise unsophisticated, bio-inert membranes to act as Bruch's membrane and support iPSC-derived retinal cells. This review presents a concise summary of the properties and function of the Bruch's membrane-retinal pigment epithelium complex, the initial pathogenic site of AMD as well as the current status for materials and fabrication approaches used to generate in vitro models of this complex tissue. Finally, this review explores required advances in the field of in vitro retinal modelling.
机译：视网膜退行性疾病，如年龄相关的黄斑变性（AMD），是全世界失明的主要原因之一，然而，彻底停止这些衰弱条件的进展的治疗是不存在的。研究人员需要复杂的模型，可以准确地代表人类视网膜组织的天然结构，以研究这些疾病。用于研究视网膜的目前的体外模型受到完全重新携带视网膜，BRUCH膜和底层脉络膜的结构和功能的能力的限制。诱导多能干细胞技术领域的最新发展已经证明了视网膜颜料上皮细胞重新承载amd样病理的能力。然而，这种研究利用了不足的生物惰性膜作为Bruch的膜并支持IPSC衍生的视网膜细胞。本综述介绍了Bruch膜 - 视网膜色素上皮综合体的性质和功能的简明摘要，AMD的初始致病部位以及用于产生该复杂组织的体外模型的材料和制造方法的当前状态。最后，本综述探讨了体外视网膜模型领域所需的进步。

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