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首页> 外文期刊>Acta biomaterialia >Glass-activated regeneration of volumetric muscle loss
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Glass-activated regeneration of volumetric muscle loss

机译：玻璃激活的体积肌损失再生

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摘要

Volumetric muscle loss (VML) resulting from injuries to skeletal muscles has profound consequences in healthcare. Current VML treatment based on the use of soft materials including biopolymers and decellularized extracellular matrix (dECM) is challenging due to their incapability of stimulating the formation of satellite cells (SCs), muscle stem cells, which are required for muscle regeneration. Additional stem cells and/or growth factors have to be incorporated in these constructs for improved efficacy. Here we report an approach by using bioactive glasses capable of regenerating VML without growth factors or stem cells. One silicate and two borate compositions with different degradation rates (2.4% for silicate 45S5; 5.3% and 30.4% for borate 8A3B and 13-9383, respectively, in simulated body fluid (SBF) at 37 degrees C for 30 days) were used for this study. Our in vitro models demonstrate the ability of ions released from bioactive glasses in promoting angiogenesis and stimulating cells to secrete critical muscle-related growth factors. We further show the activation of SCs and the regeneration of skeletal muscles in a rat VML model. Considering these promising results, this work reveals a potentially simple and safe approach to regenerating skeletal muscle defects.
机译：因骨骼肌损伤而导致的体积肌损失（VML）在医疗保健中具有深远的后果。目前基于使用包括生物聚合物和脱细胞细胞外基质（DECM）的软材料的VML处理由于它们无法刺激卫星细胞（SCS），肌肉干细胞的形成，这是肌肉再生所需的肌肉干细胞的挑战。必须在这些构建体中掺入额外的干细胞和/或生长因子以提高疗效。在这里，我们通过使用能够再生VML的生物活性眼镜而没有生长因子或干细胞来报告一种方法。使用一种硅酸盐和两个具有不同降解速率的硼酸盐组合物（硅酸盐45s5的2.4％;硼酸盐8a3b和13-9383的5.3％和30.4％，在模拟的体液（sbf）在37℃下30天）用于这项研究。我们的体外模型证明了离子从生物活性玻璃释放在促进血管生成和刺激细胞中以分泌关键肌肉相关生长因子的能力。我们进一步展示了大鼠VML模型中SCS和骨骼肌再生的激活。考虑到这些有前途的结果，这项工作揭示了一种潜在简单和安全的方法来再生骨骼肌缺陷。

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