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首页> 外文期刊>Acta biomaterialia >The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain
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The influence of body temperature on tissue stiffness, blood perfusion, and water diffusion in the mouse brain

机译：体温对小鼠脑中组织刚度，血液灌注和水扩散的影响

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While hypothermia of the brain is used to reduce neuronal damage in patients with conditions such as traumatic brain injury or stroke, little is known about how temperature affects the biophysical properties of in vivo brain tissue. Therefore, we measured shear wave speed (SWS), apparent diffusion coefficient (ADC), and cerebral blood flow (CBF) in the mouse brain at different body temperatures to investigate the relationship between temperature and tissue stiffness, water diffusion, and blood perfusion in the living brain. Multifrequency magnetic resonance elastography (MRE), diffusion-weighted imaging (DWI), and arterial spin labeling (ASL) were performed in seven mice while increasing and recording body temperature from hypothermia (28-30 degrees C) to normothermia (36-38 degrees C). SWS, ADC, and CBF were analyzed in regions of whole brain, cortex, hippocampus, and diencephalon. Our results show that SWS decreases while ADC and CBF increase from hypothermia to normothermia (whole brain SWS: -6.2%, ADC: +34.0%, CBF: +80.2%; cortex SWS: -10.1%, ADC: +30.9%, CBF: +82.4%; all p > 0.05). We found a significant inverse correlation between SWS and both ADC and CBF in all analyzed regions except diencephalon (whole brain SWS-ADC: r = -0.8, p < 0.005; SWS-CBF: r = -0.84, p < 0.005; cortex SWS-ADC: r = -0.74, p < 0.05; SWS-CBF: r = -0.65, p < 0.05). These results show that in vivo brain stiffness is inversely correlated with temperature, extracellular water mobility, and microvascular blood flow. Regional differences indicate that cortical areas are more markedly affected by hypothermia than central regions such as diencephalon. Temperature should be considered as a confounder in elastographic measurements, especially in preclinical settings.
机译：虽然大脑的低温用于减少患有创伤性脑损伤或中风的患者的神经元损伤，但关于温度如何影响体内脑组织的生物物理性质，毫无疑问。因此，在不同的体温下测量剪切波速（SWS），表观扩散系数（ADC）和脑血流（CBF），以研究温度和组织刚度，水扩散和血液灌注之间的关系活大脑。在7只小鼠中进行多频磁共振弹性术（MRE），扩散加权成像（DWI）和动脉旋转标记（ASL），同时从低温（28-30℃）中的体温增加和记录到Narmothotmia（36-38度） C）。 SWS，ADC和CBF分析了全脑，皮质，海马和Diencephalon的地区。我们的研究结果表明，随着ADC和CBF从低温增加到Narothermia（全脑SWS：-6.2％，ADC：+ 34.0％，CBF：+ 80.2％;皮质SWS：-10.1％，ADC：+ 30.9％，CBF ：+ 82.4％;所有P> 0.05）。除了Diencephalon之外的所有分析区域中，我们发现SWS和ADC和CBF之间的显着反相相关性（全脑SWS-ADC：R = -0.8，P <0.005; SWS-CBF：R = -0.84，P <0.005;皮质SWS -ADC：R = -0.74，P <0.05; SWS-CBF：r = -0.65，P <0.05）。这些结果表明，体内脑僵硬度与温度，细胞外水迁移率和微血管血流相反。区域差异表明皮质区域比低温影响比Dieyphalon等中央区域更大。温度应被视为弹性图测量中的混淆器，特别是在临床前设置。

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