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首页> 外文期刊>Acta biomaterialia >Four-dimensional bioprinting: Current developments and applications in bone tissue engineering
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Four-dimensional bioprinting: Current developments and applications in bone tissue engineering

机译：四维生物制版：骨组织工程的当前发展与应用

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摘要

Four-dimensional (4D) bioprinting, in which the concept of time is integrated with three-dimensional (3D) bioprinting as the fourth dimension, has currently emerged as the next-generation solution of tissue engineering as it presents the possibility of constructing complex, functional structures. 4D bioprinting can be used to fabricate dynamic 3D-patterned biological architectures that will change their shapes under various stimuli by employing stimuli-responsive materials. The functional transformation and maturation of printed cell-laden constructs over time are also regarded as 4D bioprinting, providing unprecedented potential for bone tissue engineering. The shape memory properties of printed structures cater to the need for personalized bone defect repair and the functional maturation procedures promote the osteogenic differentiation of stem cells. In this review, we introduce the application of different stimuliresponsive biomaterials in tissue engineering and a series of 4D bioprinting strategies based on functional transformation of printed structures. Furthermore, we discuss the application of 4D bioprinting in bone tissue engineering, as well as the current challenges and future perspectives.
机译：四维（4D）生物制品，其中时间概念与三维（3D）生物制品作为第四维集成，目前已成为组织工程的下一代解决方案，因为它呈现了构建复杂的可能性，功能结构。 4D BioPlinting可用于制造动态3D图案化的生物架构，其将通过采用刺激响应材料改变各种刺激下的形状。随着时间的推移，印刷的电池升起构建体的功能转化和成熟也被视为4D生物制版，为骨组织工程提供前所未有的潜力。印刷结构的形状记忆特性迎合了个性化骨缺损修复的需要，并且功能成熟程序促进了干细胞的骨质发生分化。在本综述中，我们在组织工程中介绍了不同刺激的生物材料和基于印刷结构的功能转换的一系列4D生物制版策略。此外，我们探讨了4D生物印刷在骨组织工程中的应用，以及当前的挑战和未来的观点。

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