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首页> 外文期刊>Acta biomaterialia >In vitro measurement of the chemical changes occurring within beta-tricalcium phosphate bone graft substitutes
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In vitro measurement of the chemical changes occurring within beta-tricalcium phosphate bone graft substitutes

机译：体外测量在β-磷酸钙骨移植物替代品中发生的化学变化

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摘要

Several mechanisms proposed to explain the osteoinductive potential of calcium phosphates involve surface mineralization ("bioactivity") and mention the occurrence of concentration gradients between the inner and the outer part of the implanted material. Determining the evolution of the local chemical environment occurring inside the pores of an implanted bone graft substitute (BGS) is therefore highly relevant. A quantitative and fast method was developed to measure the chemical changes occurring within the pores of beta-Tricalcium Phosphate (beta-TCP) granules incubated in a simulated body fluid. A factorial design of experiment was used to test the effect of particle size, specific surface area, microporosity, and purity of the beta-TCP granules. Large pH, calcium and phosphate concentration changes were observed inside the BGS and lasted for several days. The kinetics and magnitude of these changes (up to 2 pH units) largely depended on the processing and properties of the granules. Interestingly, processing parameters that increased the kinetics and magnitude of the local chemical changes are parameters considered to favor calcium phosphate osteoinduction, suggesting that the model might be useful to predict the osteoinductive potential of BGSs.
机译：提出了若干机制来解释磷酸钙的骨诱导潜力涉及表面矿化（“生物活性”），提及植入材料的内部和外部之间的浓度梯度的发生。因此，确定植入骨移植替代物（BGS）内部发生的局部化学环境的演变是高度相关的。开发了定量和快速方法以测量在模拟体液中孵育的β-三磷酸钙（β-TCP）颗粒的孔内发生的化学变化。实验的因子设计用于测试β-TCP颗粒的粒度，比表面积，微孔，纯度的效果。在BGS内观察到大的pH，钙和磷酸盐浓度变化并持续数天。这些变化的动力学和大小（最多2 pH单位）很大程度上取决于颗粒的加工和性质。有趣的是，加工参数增加了当地化学变化的动力学和幅度的参数是被认为有利于磷酸钙骨液的参数，这表明该模型可能有助于预测BGSS的骨诱导潜力。

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