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首页> 外文期刊>Acta biomaterialia >Research on an Mg-Zn alloy as a degradable biomaterial.
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Research on an Mg-Zn alloy as a degradable biomaterial.

机译：Mg-Zn合金作为可降解生物材料的研究。

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摘要

In this study a binary Mg-Zn magnesium alloy was researched as a degradable biomedical material. An Mg-Zn alloy fabricated with high-purity raw materials and using a clean melting process had very low levels of impurities. After solid solution treatment and hot working the grain size of the Mg-Zn alloy was finer and a uniform single phase was gained. The mechanical properties of this Mg-Zn alloy were suitable for implant applications, i.e. the tensile strength and elongation achieved were approximately 279.5MPa and 18.8%, respectively. The results of in vitro degradation experiments including electrochemical measurements and immersion tests revealed that the zinc could elevate the corrosion potential of Mg in simulated body fluid (SBF) and reduce the degradation rate. The corrosion products on the surface of Mg-Zn were hydroxyapatite (HA) and other Mg/Ca phosphates in SBF. In addition, the influence caused by in vitro degradation on mechanical properties was studied, and the results showed that the bending strength of Mg-Zn alloy dropped sharply in the earlier stage of degradation, while smoothly during the later period. The in vitro cytotoxicity of Mg-Zn was examined. The result 0-1 grade revealed that the Mg-Zn alloy was harmless to L-929 cells. For in vivo experiments, Mg-Zn rods were implanted into the femoral shaft of rabbits. The radiographs illustrated that the magnesium alloy could be gradually absorbed in vivo at about 2.32mm/yr degradation rate obtained by weight loss method. Hematoxylin and eosin (HE) stained section around Mg-Zn rods suggested that there were newly formed bone surrounding the implant. HE stained tissue (containing heart, liver, kidney and spleen tissues) and the biochemical measurements, including serum magnesium, serum creatinine (CREA), blood urea nitrogen (BUN), glutamic-pyruvic transaminase (GPT) and creatine kinase (CK) proved that the in vivo degradation of Mg-Zn did not harm the important organs. Moreover, no adverse effects of hydrogen generated by degradation had been observed and also no negative effects caused by the release of zinc were detected. These results suggested that the novel Mg-Zn binary alloy had good biocompatibility in vivo.
机译：在该研究中，研究了二元Mg-Zn镁合金作为可降解的生物医学材料。用高纯度原料和使用清洁熔化过程制造的Mg-Zn合金具有非常低的杂质。在固溶处理和热工作后，Mg-Zn合金的晶粒尺寸更细，获得均匀的单相。该Mg-Zn合金的机械性能适用于植入物应用，即所达到的拉伸强度和伸长率分别为约279.5MPa和18.8％。体外降解实验的结果包括电化学测量和浸渍试验，显示锌可以提高模拟体液（SBF）中Mg的腐蚀电位并降低降解速率。 Mg-Zn表面上的腐蚀产物是羟基磷灰石（HA）和SBF中的其他Mg / Ca磷酸盐。此外，研究了在体外降解机械性能引起的影响，结果表明，在较早的劣化期间，Mg-Zn合金的弯曲强度急剧下降，同时在后期平稳地进行平稳。检查Mg-Zn的体外细胞毒性。结果0-1级显示Mg-Zn合金对L-929细胞无害。对于体内实验，将Mg-Zn棒植入兔子的股骨轴中。射线照片示出了通过减肥方法获得的约2.32mm / Yr降解速率，镁合金可以逐渐被体内吸收。苏木精和曙红（He）染色围绕Mg-Zn棒的部分表明植入物的新形成的骨骼。他染色了组织（含有心脏，肝脏，肾脏和脾脏组织）和生物化学测量，包括血清镁，血清肌酐（CREA），血尿素氮（BUN），谷氨酸 - 丙酮转氨酶（GPT）和肌酸激酶（CK）证明Mg-Zn的体内降解没有损害重要器官。此外，已经观察到通过降解产生的氢的不利影响，并且也没有通过检测到锌的释放引起的负面影响。这些结果表明，新型Mg-Zn二元合金在体内具有良好的生物相容性。

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  • 来源
    《Acta biomaterialia》 |2010年第2期|共15页
  • 作者

    Zhang S; Zhang X; Zhao;

  • 作者单位

    State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai People's Republic of China.;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物医学工程;
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