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首页> 外文期刊>Acta biomaterialia >Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy.
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Relationship between microstructure, cytotoxicity and corrosion properties of a Cu-Al-Ni shape memory alloy.

机译：Cu-Al-Ni形状记忆合金微观结构，细胞毒性和腐蚀性能的关系。

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摘要

Cu-Al-Ni shape memory alloys (SMAs) have been investigated as materials for medical devices, but their biomedical application is still limited. The aim of this work was to compare the microstructure, corrosion and cytotoxicity in vitro of a Cu-Al-Ni SMA. Rapidly solidified (RS) thin ribbons, manufactured via melt spinning, were used for the tests. The control alloy was a permanent mould casting of the same composition, but without shape memory effect. The results show that RS ribbons are significantly more resistant to corrosion compared with the control alloy, as judged by the lesser release of Cu and Ni into the conditioning medium. These results correlate with the finding that RS ribbons were not cytotoxic to L929 mouse fibroblasts and rat thymocytes. In addition, the RS ribbon conditioning medium inhibited cellular proliferation and IL-2 production by activated rat splenocytes to a much lesser extent. The inhibitory effects were almost completely abolished by conditioning the RS ribbons in culture medium for 4 weeks. Microstructural analysis showed that RS ribbons are martensitic, with boron particles as a minor phase. In contrast, the control Cu-Al-Ni alloy had a complex multiphase microstructure. Examination of the alloy surfaces after conditioning by energy dispersive X-ray and Auger electron spectroscopy showed the formation of Cu and Al oxide layers and confirmed that the metals in RS ribbons are less susceptible to oxidation and corrosion compared with the control alloy. In conclusion, these results suggest that rapid solidification significantly improves the corrosion stability and biocompatibility in vitro of Cu-Al-Ni SMA ribbons.
机译：已经研究了Cu-Al-Ni形状记忆合金（SMA）作为医疗装置的材料，但它们的生物医学应用仍然有限。这项工作的目的是比较Cu-Al-Ni SMA体外的微观结构，腐蚀和细胞毒性。通过熔融纺丝制造的快速凝固（RS）薄带用于测试。控制合金是相同组成的永久模具铸造，但没有形状记忆效果。结果表明，与对照合金相比，RS丝带明显更耐腐蚀，与Cu和Ni的释放释放到调理培养基中判断。这些结果与RS丝带不是细胞毒性至L929小鼠成纤维细胞和大鼠胸腺细胞的发现相关。此外，RS带状调节培养基通过活化的大鼠脾细胞抑制细胞增殖和IL-2产生，以更大的程度。通过将培养基中的RS带调节4周，几乎完全废除了抑制作用。微观结构分析表明，RS丝带是马氏体，硼颗粒为小相。相反，对照Cu-Al-Ni合金具有复杂的多相微结构。通过能量分散X射线和螺旋钻电子光谱调节后的合金表面的检查显示Cu和Al氧化物层的形成，并确认RS丝带中的金属与对照合金相比的氧化和腐蚀的影响较小。总之，这些结果表明，快速凝固显着提高了Cu-Al-Ni SMA带体外的腐蚀稳定性和生物相容性。

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