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首页> 外文期刊>Acta biomaterialia >Direct write assembly of calcium phosphate scaffolds using a water-based hydrogel.
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Direct write assembly of calcium phosphate scaffolds using a water-based hydrogel.

机译：使用水基水凝胶直接写磷酸钙支架组装。

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The development of materials to support bone regeneration requires flexible fabrication technologies able to tailor chemistry and architecture for specific applications. In this work we describe the preparation of ceramic-based inks for robotic-assisted deposition (robocasting) using Pluronic F-127 solutions. This approach allows the preparation of pseudoplastic inks with solid contents ranging between 30 and 50 vol.%, enabling them to flow through a narrow printing nozzle while supporting the weight of the printed structure. Ink formulation does not require manipulation of the pH or the use of highly volatile organic components. Therefore, the approach can be used to prepare materials with a wide range of compositions, and here we use it to build hydroxyapatite (HA), beta-tricalcium phosphate (beta-TCP) and biphasic (HA/beta-TCP) structures. The flow of the inks is controlled by the Pluronic content and the particle size distribution of the ceramic powders. The use of wide size distributions favors flow through the narrow printing nozzles and we have been able to use printing nozzles as narrow as 100 microm in diameter, applying relatively low printing pressures. The microporosity of the printed lines increases with increasing Pluronic content and lower sintering temperatures. Microporosity can play a key role in determining the biological response to the materials, but it also affects the strength of the structure.
机译：支持骨再生的材料的开发需要灵活的制造技术，能够针对特定应用定制化学和架构。在这项工作中，我们使用Pluronic F-127解决方案描述了用于机器人辅助沉积（Robocasting）的陶瓷基油墨的制备。这种方法允许制备具有固体含量的假塑性油墨在30到50体积之间的固体含量。％，使它们能够在支撑印刷结构的重量的同时流过窄印刷喷嘴。油墨配方不需要操纵pH或使用高挥发性有机组分。因此，该方法可用于制备具有多种组合物的材料，并且在这里，我们使用它来构建羟基磷灰石（HA），β-磷酸钙（β-TCP）和双相（HA / BETA-TCP）结构。墨水的流动由Pluronic含量和陶瓷粉末的粒度分布控制。宽尺寸分布的使用涉及通过窄的印刷喷嘴流动，并且我们已经能够使用印刷喷嘴作为直径为100微米的印刷喷嘴，施加相对较低的印刷压力。随着Pluronic含量的增加和较低的烧结温度，印刷线的微孔率增加。微孔度可以在确定对材料的生物响应中起关键作用，但它也影响了结构的强度。

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