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首页> 外文期刊>Acta biomaterialia >Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester.
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Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester.

机译：用于组织工程的脚手架由高温聚酯的非等温超临界二氧化碳发泡制造的组织工程。

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摘要

Porous scaffolds of a random co-polymer of omega-pentadecalactone (PDL) and epsilon-caprolactone (CL) (poly(PDL-CL)), synthesized by biocatalysis, were fabricated by supercritical carbon dioxide (scCO(2)) foaming. The co-polymer, containing 31 mol.% CL units, is highly crystalline (T(m) = 82 degrees C, DeltaH(m) = 105 J g(-1)) thanks to the ability of the two monomer units to co-crystallize. The co-polymer can be successfully foamed upon homogeneous absorption of scCO(2) at T > T(m). The effect of soaking time, depressurization rate and cooling rate on scaffold porosity, pore size distribution and pore interconnectivity was investigated by micro X-ray computed tomography. Scaffolds with a porosity in the range 42-76% and an average pore size of 100-375 microm were successfully obtained by adjusting the main foaming parameters. Process conditions in the range investigated did not affect the degree of crystallinity of poly(PDL-CL) scaffolds. A preliminary study of the mechanical properties of the scaffolds revealed that poly(PDL-CL) foams may find application in the regeneration of cartilage tissue.
机译：通过生物分析合成的ω-五甲烷酮（PDL）和ε-己内酯（PDL）和ε-己内酯（CL）（Poly（PDL-Cl））的多孔支架，通过超临界二氧化碳（SCCO（2））发泡来制造。含有31摩尔％的Cl单元的共聚物是高度结晶（T（m）= 82℃，Δ（m）= 105jg（-1））由于两种单体单元与CO的能力-结晶。共聚物可以在T> T（M）的均匀吸收时成功发泡。通过微X射线计算断层扫描研究了浸泡时间，减压率和冷却速率对支架孔隙率，孔径分布和孔隙互连的影响。通过调节主要发泡参数，成功地获得了42-76％范围内的孔隙率和平均孔径为100-375微米的支架。研究范围的工艺条件不影响聚（PDL-CL）支架的结晶度。对支架的力学性质的初步研究表明，聚（PDL-CL）泡沫可以在软骨组织的再生中施用。

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