• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues
【24h】

Injectable hydrogels with high fixed charge density and swelling pressure for nucleus pulposus repair: Biomimetic glycosaminoglycan analogues

机译：具有高固定电荷密度的可注射水凝胶和核浆气的溶胀压力：仿生糖胺聚糖类似物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The load-bearing biomechanical role of the intervertebral disc is governed by the composition and organization of its major macromolecular components, collagen and aggrecan. The major function of aggrecan is to maintain tissue hydration, and hence disc height, under the high loads imposed by muscle activity and body weight. Key to this role is the high negative fixed charge of its glycosaminoglycan side chains, which impart a high osmotic pressure to the tissue, thus regulating and maintaining tissue hydration and hence disc height under load. In degenerate discs, aggrecan degrades and is lost from the disc, particularly centrally from the nucleus pulposus. This loss of fixed charge results in reduced hydration and loss of disc height; such changes are closely associated with low back pain. The present authors developed biomimetic glycosaminoglycan analogues based on sulphonate-containing polymers. These biomimetics are deliverable via injection into the disc where they polymerize in situ, forming a non-degradable, nuclear "implant" aimed at restoring disc height to degenerate discs, thereby relieving back pain. In vitro, these glycosaminoglycan analogues possess appropriate fixed charge density, hydration and osmotic responsiveness, thereby displaying the capacity to restore disc height and function. Preliminary biomechanical tests using a degenerate explant model showed that the implant adapts to the space into which it is injected and restores stiffness. These hydrogels mimic the role taken by glycosaminoglycans in vivo and, unlike other hydrogels, provide an intrinsic swelling pressure, which can maintain disc hydration and height under the high and variable compressive loads encountered in vivo.
机译：椎间盘的承载生物力学作用受其主要大分子组分，胶原蛋白和聚集体的组成和组织的管辖。聚集体的主要功能是在肌肉活性和体重施加的高负荷下保持组织水合，并因此保持盘高。该作用的关键是其糖胺聚糖侧链的高负固定电荷，其为组织赋予高渗透压，从而调节和维持在负载下的组织水合并因此在载体中保持圆盘高度。在稀释盘中，聚集体降解并从盘中丢失，特别是从细胞核脉搏中居中。这种固定电荷的损失导致圆盘高的水合和损失降低;这种变化与腰痛密切相关。本作者基于含磺酸盐的聚合物开发了仿生糖胺聚糖类似物。这些生物体可通过注射输送到它们原位聚合的盘中，形成旨在恢复圆盘高度的不可降解的核“植入物”，从而缓解疼痛。在体外，这些糖胺聚糖类似物具有适当的固定电荷密度，水合和渗透响应性，从而显示恢复盘高度和功能的能力。使用退化介绍模型的初步生物力学试验表明，植入物适应其注入并恢复刚度的空间。这些水凝胶模仿体内糖胺聚糖所采取的作用，与其他水凝胶不同，提供固有的溶胀压力，其可以在体内遇到的高和可变压缩载量下保持盘水合和高度。

著录项

  • 来源
    《Acta biomaterialia》 |2014年第3期|共10页
  • 作者

    SivanS.S.; RobertsS.; UrbanJ.P.G.; MenageJ.; BramhillJ.; CampbellD.; FranklinV.J.; LydonF.; MerkherY.; MaroudasA.; TigheB.J.;

  • 作者单位

    Department of Physiology Anatomy and Genetics University of Oxford Parks Road Oxford OX1 3PT;

    Spinal Studies RJAH Orthopaedic Hospital and ISTM Keele University Oswestry Shropshire SY10 7AG;

    Department of Physiology Anatomy and Genetics University of Oxford Parks Road Oxford OX1 3PT;

    Spinal Studies RJAH Orthopaedic Hospital and ISTM Keele University Oswestry Shropshire SY10 7AG;

    Biomaterials Research Unit School of Engineering and Applied Science Aston University Birmingham;

    Biomaterials Research Unit School of Engineering and Applied Science Aston University Birmingham;

    Biomaterials Research Unit School of Engineering and Applied Science Aston University Birmingham;

    Biomaterials Research Unit School of Engineering and Applied Science Aston University Birmingham;

    Department of Biomedical Engineering Technion-Israel Institute of Technology Haifa 32000 Israel;

    Department of Biomedical Engineering Technion-Israel Institute of Technology Haifa 32000 Israel;

    Biomaterials Research Unit School of Engineering and Applied Science Aston University Birmingham;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Glycosaminoglycan Disc repair; Hydrogel; Intervertebral disc; mnimally invasive; swelling pressure;

    机译：糖胺聚糖圆盘修复;水凝胶;椎间盘;周围侵入性;膨胀压力;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号