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首页> 外文期刊>Acta biomaterialia >Poly(amido-amine)-based hydrogels with tailored mechanical properties and degradation rates for tissue engineering
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Poly(amido-amine)-based hydrogels with tailored mechanical properties and degradation rates for tissue engineering

机译：聚（氨基胺）的水凝胶，具有量身定制的机械性能和组织工程的降解率

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摘要

Poly(amido-amine) (PAA) hydrogels containing the 2,2-bisacrylamidoacetic acid-4-amminobutyl guanidine monomeric unit have a known ability to enhance cellular adhesion by interacting with the arginin-glycin-aspartic acid (RGD)-binding αVβ3 integrin, expressed by a wide number of cell types. Scientific interest in this class of materials has traditionally been hampered by their poor mechanical properties and restricted range of degradation rate. Here we present the design of novel biocompatible, RGD-mimic PAA-based hydrogels with wide and tunable degradation rates as well as improved mechanical and biological properties for biomedical applications. This is achieved by radical polymerization of acrylamide-terminated PAA oligomers in both the presence and absence of 2-hydroxyethylmethacrylate. The degradation rate is found to be precisely tunable by adjusting the PAA oligomer molecular weight and acrylic co-monomer concentration in the starting reaction mixture. Cell adhesion and proliferation tests on Madin-Darby canine kidney epithelial cells show that PAA-based hydrogels have the capacity to promote cell adhesion up to 200% compared to the control. Mechanical tests show higher compressive strength of acrylic chain containing hydrogels compared to traditional PAA hydrogels.
机译：聚（氨基胺）（PAA）水凝胶含有2,2-双相酰胺酰亚乙酸-4-氨丁基胍单体单元具有通过与精氨酸 - 甘油 - 天冬氨酸（RGD）相互作用而增强细胞粘附的能力， - 缠结αvβ3整联蛋白，由各种细胞类型表示。对这类材料的科学兴趣传统上被他们的机械性能差和限制的降解率范围阻碍了。在这里，我们介绍了具有宽和可调的降解速率的新型生物相容性，RGD模拟PAA水凝胶，以及改善生物医学应用的机械和生物学性能。这是通过在存在和不存在2-羟乙基甲基丙烯酸酯中的丙烯酰胺封端的PAA低聚物的自由基聚合来实现的。发现降解速率通过在起始反应混合物中调节PAA低聚物分子量和丙烯酸共聚单体浓度来精确可调。对Madin-Darby犬肾上皮细胞的细胞粘附和增殖试验表明，与对照相比，PAA的水凝胶具有促进细胞粘合至200％的电池粘附。与传统PAA水凝胶相比，机械试验显示含有水凝胶的丙烯酸链的较高抗压强度。

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  • 来源
    《Acta biomaterialia》 |2014年第3期|共10页
  • 作者

    MartelloF.; TocchioA.; TamplenizzaM.; GergesI.; PistisV.; RecentiR.; BortolinM.; DelFabbroM.; ArgentiereS.; MilaniP.; LenardiC.;

  • 作者单位

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy;

    SEMM European School of Molecular Medicine Campus IFOM-IEO Via Adamello 16 20139 Milano Italy;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy;

    Dipartimento di Scienze Biomediche Chirurgiche Ed Odontoiatriche Università Degli Studi di Milano;

    Dipartimento di Scienze Biomediche Chirurgiche Ed Odontoiatriche Università Degli Studi di Milano;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy CIMaINa Dipartimento di Fisica;

    Fondazione Filarete Viale Ortles 22/4 20139 Milano Italy CIMaINa Dipartimento di Fisica;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Biomimetics; Hydrogels; Structure-property relationship; Tissue engineering;

    机译：生物体;水凝胶;结构 - 财产关系;组织工程;

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