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首页> 外文期刊>Acta biomaterialia >Mussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery
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Mussel-inspired protein-mediated surface functionalization of electrospun nanofibers for pH-responsive drug delivery

机译：贻贝激发蛋白介导的蛋白介导的电纺纳米纤维表面官能化，用于pH响应药物递送

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摘要

pH-responsive drug delivery systems could mediate drug releasing rate by changing the pH values at specific times as per the pathophysiological need of the disease. This paper demonstrates that a mussel-inspired protein polydopamine coating can tune the loading and releasing rate of charged molecules from electrospun poly(ε-caprolactone) (PCL) nanofibers in solutions with different pH values. In vitro release profiles show that the positive charged molecules release significantly faster in acidic than those in neutral and basic environments within the same incubation time. The results of fluorescein diacetate staining and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays show the viability of cancer cells after treatment with doxorubicin-released media at different pH values qualitatively and quantitatively, indicating that the media containing doxorubicin that were released in solutions at low pH values could kill a significantly higher number of cells than those released in solutions at high pH values. Together, the pH-responsive drug delivery systems based on polydopamine-coated PCL nanofibers could have potential application in the oral delivery of anticancer drugs for treating gastric cancer and in vaginal delivery of anti-viral drugs or anti-inflammatory drugs, which could raise their efficacy, deliver them to the specific target and minimize their toxic side effects.
机译：pH-响应药物递送系统可以通过根据疾病的病理生理学需求改变特定时间的pH值来调解药物释放率。本文表明，贻贝启发的蛋白质多斑胺涂层可以在具有不同pH值的溶液中从Electrom ow Poly（ε-己内酯）（PCL）纳米纤维中的带电分子的装载和释放速率。体外释放曲线表明，正电荷分子在酸性中释放得比相同孵育时间内的中性和基本环境中的酸性显着更快。荧光素二乙酸酯染色的结果和3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑鎓溴化溴化铵测定显示癌细胞在定性和定量的不同pH值下用不同的pH值处理后的癌细胞的可行性，表明含有在低pH值溶液中释放的多柔比星的培养基可以杀死比在高pH值中溶液中释放的细胞数量显着更高的细胞。基于聚二胺涂覆的PCL纳米纤维的pH-响应药物递送系统在一起可能在口服递送抗癌药物和阴道递送抗病毒药物或抗炎药物的抗癌药物中的潜在应用，这可能会提高他们的抗病毒药物或抗炎药功效，将它们递送到特定的目标并最大限度地减少其毒副作用。

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  • 来源
    《Acta biomaterialia》 |2014年第3期|共9页
  • 作者

    JiangJ.; XieJ.; MaB.; BartlettD.E.; XuA.; WangC.-H.;

  • 作者单位

    Marshall Institute for Interdisciplinary Research Center for Diagnostic Nanosystems Marshall;

    Marshall Institute for Interdisciplinary Research Center for Diagnostic Nanosystems Marshall;

    Marshall Institute for Interdisciplinary Research Center for Diagnostic Nanosystems Marshall;

    Marshall Institute for Interdisciplinary Research Center for Diagnostic Nanosystems Marshall;

    Key Laboratory of Ion Beam Bioengineering Hefei Institutes of Physical Sciences Chinese Academy;

    Department of Chemical and Biomolecular Engineering National University of Singapore 4;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Drug delivery; Electrospun fibers; pH sensitive; Poly(ε-caprolactone); Polydopamine coating;

    机译：药物递送;电纺纤维;pH敏感;聚（ε-己内酯）;聚二胺涂层;

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