Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues.

F Han; S Liu; X Liu; Y Pei; S Bai; H Zhao; Q Lu; F Ma; D L Kaplan; H Zhu

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Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues.

机译：编织丝织物 - 增强丝纳米纤维支架，用于再生承载软组织。

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Although three-dimensional (3-D) porous regenerated silk scaffolds with outstanding biocompatibility, biodegradability and low inflammatory reactions have promising application in different tissue regeneration, the mechanical properties of regenerated scaffolds, especially suture retention strength, must be further improved to satisfy the requirements of clinical applications. This study presents woven silk fabric-reinforced silk nanofibrous scaffolds aimed at dermal tissue engineering. To improve the mechanical properties, silk scaffolds prepared by lyophilization were reinforced with degummed woven silk fabrics. The ultimate tensile strength, elongation at break and suture retention strength of the scaffolds were significantly improved, providing suitable mechanical properties strong enough for clinical applications. The stiffness and degradation behaviors were then further regulated by different after-treatment processes, making the scaffolds more suitable for dermal tissue regeneration. The in vitro cell culture results indicated that these scaffolds maintained their excellent biocompatibility after being reinforced with woven silk fabrics. Without sacrifice of porous structure and biocompatibility, the fabric-reinforced scaffolds with better mechanical properties could facilitate future clinical applications of silk as matrices in skin repair.

机译：虽然三维（3-D）多孔再生丝支架具有出色的生物相容性，生物降解性和低炎症反应在不同的组织再生中具有很有希望的应用，但必须进一步改善再生支架，尤其是缝合保留强度的机械性能以满足要求临床应用。本研究介绍了针织丝织物增强丝纳米纤维支架，旨在皮肤组织工程。为了改善机械性能，通过脱胶的织物织物增强了通过冻干制备的丝支架。支架的最终拉伸强度，断裂伸长率和支架的缝合滞留强度，为临床应用提供适合的机械性能。然后通过不同的后处理过程进一步调节刚度和降解行为，使支架更适合于皮肤组织再生。体外细胞培养结果表明，这些支架在用织造织物加固后保持其优异的生物相容性。不牺牲多孔结构和生物相容性，具有更好机械性能的织物增强支架可以促进丝绸作为皮肤修复中的矩阵的未来临床应用。

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《Acta biomaterialia》 |2014年第2期|共10页
作者
F Han; S Liu; X Liu; Y Pei; S Bai; H Zhao; Q Lu; F Ma; D L Kaplan; H Zhu;
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Research Center of Materials Science Beijing Institute of Technology Beijing 100081 China;

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正文语种 eng
中图分类普通生物学;
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1. Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues. [J] . F Han, S Liu, X Liu, Acta biomaterialia . 2014,第2期

机译：编织的丝织物增强的丝纳米纤维支架，用于再生承重的软组织。
2. In vitro study of novel microparticle based silk fibroin scaffold with osteoblast-like cells for load-bearing osteo-regenerative applications [J] . Parekh Nimisha, Hushye Chandni, Warunkar Saniya, RSC Advances . 2017,第43期

机译：具有骨细胞样细胞的新微粒丝素蛋白支架的体外研究，用于携带载有骨质细胞的骨质细胞再生应用
3. In vitro study of novel microparticle based silk fibroin scaffold with osteoblast-like cells for load-bearing osteo-regenerative applications [J] . Nimisha Parekh, Chandni Hushye, Saniya Warunkar, RSC Advances . 2017,第43期

机译：体外研究新型基于微粒的丝素蛋白支架与成骨细胞样细胞，用于承重骨再生应用

4. In Vivo Evaluation of Bilayered Silk/Silk-Nano CaP Scaffolds for Osteochondral Regeneration [C] . Le-Ping Yan, Joana Silva-Correia, Carlos Vilera, Society for Biomaterials annual meeting and exposition . 2015

机译：骨/软骨-纳米CaP双层支架骨软骨再生的体内评价。

5. Silk Fibroin/Nanohydroxyapatite Porous Scaffolds for Bone Regeneration [D] . de Costa Ribeiro, Marta Raquel. 2017

机译：丝素蛋白/纳米羟基磷灰石多孔支架用于骨再生

6. Electrospun silk fibroin/poly(lactide-co-ε-caprolactone) nanofibrous scaffolds for bone regeneration [O] . Zi Wang, Ming Lin, Qing Xie, 1988

机译：电纺丝素蛋白/聚（丙交酯-ε-己内酯）纳米纤维支架用于骨再生

7. In vitro study of novel microparticle based silk fibroin scaffold with osteoblast-like cells for load-bearing osteo-regenerative applications [O] . Nimisha Parekh, Chandni Hushye, Saniya Warunkar, 2017

机译：具有骨细胞样细胞的新微粒丝素蛋白支架的体外研究，用于携带载有骨质细胞的骨质细胞再生应用

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机译：干丝直接不皱纸的生产工艺干丝直接不皱纸的生产工艺直接干丝丝绸纸的造纸工艺真丝软纸中不起皱的压延制品的生产及直接不干丝产品的生产工艺皱

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机译：用于丝绢，绢丝和绢丝染色的SERICIN SOAP替代品的制造过程。

5. Electrospun silk fibroin blend nanofibrous scaffold and its use in tissue engineering [P] . 外国专利： IN2012KO00713A . 2015-08-14

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Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues.

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