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首页> 外文期刊>Acta biomaterialia >Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis--a review.
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Significance of calcium phosphate coatings for the enhancement of new bone osteogenesis--a review.

机译：磷酸钙涂料对新型骨骨质骨质骨质增强的意义 - 综述。

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摘要

A systematic analysis of results available from in vitro, in vivo and clinical trials on the effects of biocompatible calcium phosphate (CaP) coatings is presented. An overview of the most frequently used methods to prepare CaP-based coatings was conducted. Dense, homogeneous, highly adherent and biocompatible CaP or hybrid organic/inorganic CaP coatings with tailored properties can be deposited. It has been demonstrated that CaP coatings have a significant effect on the bone regeneration process. In vitro experiments using different cells (e.g. SaOS-2, human mesenchymal stem cells and osteoblast-like cells) have revealed that CaP coatings enhance cellular adhesion, proliferation and differentiation to promote bone regeneration. However, in vivo, the exact mechanism of osteogenesis in response to CaP coatings is unclear; indeed, there are conflicting reports of the effectiveness of CaP coatings, with results ranging from highly effective to no significant or even negative effects. This review therefore highlights progress in CaP coatings for orthopaedic implants and discusses the future research and use of these devices. Currently, an exciting area of research is in bioactive hybrid composite CaP-based coatings containing both inorganic (CaP coating) and organic (collagen, bone morphogenetic proteins, arginylglycylaspartic acid etc.) components with the aim of promoting tissue ingrowth and vascularization. Further investigations are necessary to reveal the relative influences of implant design, surgical procedure, and coating characteristics (thickness, structure, topography, porosity, wettability etc.) on the long-term clinical effects of hybrid CaP coatings. In addition to commercially available plasma spraying, other effective routes for the fabrication of hybrid CaP coatings for clinical use still need to be determined and current progress is discussed.
机译：提出了对体外可获得的结果的系统分析，体内和临床试验提出了生物相容性磷酸钙（帽）涂层的效果。进行了制备基于帽涂层的最常用方法的概述。可以沉积致密，均匀，高度粘附和生物相容性盖或杂种有机/无机帽涂层，可以沉积具有定制性能的。已经证明盖帽涂层对骨再生过程具有显着影响。使用不同细胞的体外实验（例如，SAOS-2，人间充质干细胞和成骨细胞样细胞）表明帽涂层增强了细胞粘附，增殖和分化以促进骨再生。然而，在体内，恢复帽涂层的骨质发生的确切机制尚不清楚;实际上，存在帽涂层有效性的矛盾的报告，结果范围从高度有效，没有显着甚至负面影响。因此，本综述突出了矫形植入物的盖帽涂层的进展，并讨论了这些设备的未来研究和使用。目前，令人兴奋的研究领域是含有无机（帽涂层）和有机（胶原，骨形态发生蛋白，氨基乙基天使酸等）组分的生物活性混合复合帽的涂料，其旨在促进组织成长和血管化。进一步的调查是揭示植入物设计，外科手术和涂层特性（厚度，结构，形貌，孔隙，润湿性等）对杂交帽涂层的长期临床影响的相对影响。除了市售的等离子体喷涂之外，还需要确定用于制造用于临床用途的混合帽涂层的其他有效途径，并且仍然讨论了电流进展。

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