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首页> 外文期刊>Acta biomaterialia >Microfluidic fabrication of 6-methoxyethylamino numonafide-eluting magnetic microspheres.
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Microfluidic fabrication of 6-methoxyethylamino numonafide-eluting magnetic microspheres.

机译：6-甲氧基乙基氨基NUMONAIDE洗脱磁性微球的微流体制造。

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Recently, 6-methoxyethylamino numonafide (MEAN) exhibited potent inhibition of hepatocellular carcinoma (HCC) cell growth and less systemic toxicity than amonafide. MEAN may serve as an ideal candidate for the treatment of HCC; however, liver-directed, selective infusion methods may be critical to maximize the MEAN dose delivered to the targeted tumors. This study describes the microfluidic fabrication of MEAN-eluting ultrasmall superparamagnetic iron oxide (USPIO) nanocluster-containing alginate microspheres (MEAN-magnetic microspheres) intended for selective transcatheter delivery to HCC. The resulting drug delivery platform was mono-disperse, microsphere sizes were readily controlled based on channel flow rates during synthesis procedures, and drug release rates from the microspheres could be readily controlled with the introduction of USPIO nanoclusters. The MR relaxivity properties of the microspheres suggest the feasibility of in vivo imaging after administration, and these microspheres exhibited potent therapeutic effects significantly inhibiting cell growth inducing apoptosis in hepatoma cells.
机译：最近，6-甲氧基乙基氨基NUMONAINE（平均）表现出肝细胞癌（HCC）细胞生长的有效抑制，并且劣质的全身毒性而不是Amonafide。意思可以作为治疗HCC的理想候选者;然而，肝导向，选择性输注方法可能是至关重要的，以最大化递送到靶向肿瘤的平均剂量。该研究描述了含有用于选择性转截管递送至HCC的平均含有超顺磁性氧化铁（USPIO）含含藻酸盐的微球（平均磁性微球）的微流体制造。得到的药物递送平台是单分散的，基于合成程序期间的通道流速容易地控制微球尺寸，并且可以随着USPIO纳米能器的引入容易地控制来自微球的药物释放速率。微球的MR放松性质表明，给药后体内成像的可行性，这些微球表现出显着抑制肝癌细胞细胞凋亡的有效治疗效果。

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