...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Zwitterionic fibrous polypropylene assembled with amphiphatic carboxybetaine copolymers for hemocompatible blood filtration
【24h】

Zwitterionic fibrous polypropylene assembled with amphiphatic carboxybetaine copolymers for hemocompatible blood filtration

机译：两性离子纤维聚丙烯组装成含有血液相处的血液过滤的两亲羧基丙烯共聚物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study serves three main functions. First, it presents a novel random copolymer, made of octadecyl acrylate hydrophobic blocks and 2-(dimethylamino)ethyl methacrylate hydrophilic groups, and it zwitterionic form. Second, random copolymer and zwitterionic random copolymer, OmDn and Z-OmDn, are used to modify polypropylene membranes by evaporation coating. Our investigations unveil that this method leads to sufficiently stable self-assembling provided a minimum number of hydrophobic repeat units of 77, which also corresponds to a hydrophobic degree of 74%. Third, antifouling and hemocompatible properties of membranes are thoroughly investigated using all types of blood cells separately, as well as challenging membranes against whole blood in static and dynamic conditions. Membranes modified with zwitterionic copolymer containing 26% of zwitterionic groups are shown to be highly antifouling and hemocompatible, for a coating density as low as 0.2 mg/cm(2). Their application in a specially designed blood filtration module enabled to almost totally inhibit blood cells interactions with membrane material, as well as to importantly reduce platelet activation in the permeate (2.5-fold reduction).
机译：本研究提供了三种主要功能。首先，它提出了一种新型无规共聚物，由丙烯酸丙烯酸酯疏水嵌段和2-（二甲基氨基）乙基丙烯酸乙酯亲水基团，以及两性离子形式制成。第二，无规共聚物和两性离子无规共聚物，OMDN和Z-OMDN，通过蒸发涂层改变聚丙烯膜。我们的调查推出了该方法的自组装提供足够稳定的自组装，提供了77的最小疏水重复单元，其对应于74％的疏水程度。第三，使用各种类型的血细胞分别使用所有类型的血细胞彻底研究膜的防污和血液相容性，以及静态和动态条件下的全血的挑战性。用含有26％的两性离子基团的两性离子共聚物改性的膜被示出为高度防污和血液相处，涂层密度低至0.2mg / cm（2）。它们在特殊设计的血液过滤模块中的应用使得几乎完全抑制与膜材料的相互作用，以及重要地降低渗透物中的血小板活化（减少2.5倍）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号