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首页> 外文期刊>Biomacromolecules >'Schizophrenic' Hemocompatible Copolymers via Switchable Thermoresponsive Transition of Nonionic/Zwitterionic Block Self-Assembly in Human Blood
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'Schizophrenic' Hemocompatible Copolymers via Switchable Thermoresponsive Transition of Nonionic/Zwitterionic Block Self-Assembly in Human Blood

机译：“精神分裂症”血液相处的共聚物，通过可切换的热反应性过渡的非离子/两性离子块自组装在人血液中的转变

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摘要

"Schizophrenic" diblock copolymers containing nonionic and zwitterionic blocks were prepared with well-controlled molecular weights via atom-transfer radical polymerization (ATRP). In this work, we report a systematic study of how morphological changes of poly(N-isopropylacry-lamide)-block-poly(sulfobetaine methacrylate) (PNIPAAm-b-PSBMA) copolymers affect hemocompatibility in human blood solution. The "schizophrenic" behavior of PNIPAAm-b-PSBMA was observed by 'H NMR, dynamic light scattering (LCST) and upper critical solution temperature (UCST) in aqueous solution. Below the UCST of PSBMA block, micelles were obtained with a core of insoluble PSBMA association and a shell of soluble PNIPAAm, whereas the opposite micelle structure was observed above the LCST of PNIPAAm block In between the UCST and LCST, unimers with both soluble blocks were detected. Hydrodynamic size of prepared polymers and copolymers is determined to illustrate the correlations between intermolecular nonionic/zwitterionic associations and blood compatibility of PNIPAAm, PNIPAAm-b-PSBMA, and PSBMA suspension in human blood. Human fibrinogen adsorption onto the PNIPAAm-b-PSBMA copolymers from single-protein solutions was measured by DLS to determine the nonfouling stability of copolymer suspension. The new nonfouling nature of PNIPAAm-b-PSBMA copolymers was demonstrated to show extremely high anticoagulant activity and antihemolytic activity in human blood over a wide range of explored temperatures from 4 to 40 °C. The temperature-independent blood compatibility of nonionic/zwitterionic block copolymer along with their schizophrenic phase behavior in aqueous solution suggests their potential in blood-contacting applications.
机译：通过原子转移自由基聚合（ATRP）具有良好控制的分子量，制备含有非离子和两性离子嵌段的非离子和两性离子嵌段的二嵌段共聚物。在这项工作中，我们报告了对聚（N-异丙基 - 夹层）的形态变化 - 聚（N-异丙基 - 夹层） - Block-poly（磺基甲酸甲酯）（PNIPAAM-B-PSBMA）共聚物的系统研究，影响人血液溶液中的血液相位性。通过“H NMR，动态光散射（LCST）和水溶液上临界溶液温度（UCST）观察PNIPAAM-B-PSBMA的”精神分裂症“行为。在PSBMA块的UCST下方，用不溶的PSBMA结合的核心获得胶束，而可溶性泊匹帕的壳，而在UCST和LCST之间的PNIPAAM嵌段的LCST上方观察到相反的胶束结构，用两个可溶性块的单倍检测到。确定制备的聚合物和共聚物的流体动力学尺寸以说明分子间非离子/两性离子缔合和泊匹帕，PNIPAAM-B-PSBMA和人类血液中PSBMA悬浮液之间的血液相容性之间的相关性。通过DLS测量人纤维蛋白原吸附于单蛋白溶液中的PNIPAAM-B-PSBMA共聚物，以确定共聚物悬浮液的非折叠稳定性。证明了泊帕-B-PSBMA共聚物的新的非污染性质，以在4至40℃的探索温度范围内的人体血液中显示出极高的抗凝血活性和抗激溶性活性。非离子/两性离子嵌段共聚物的温度无关血液相容性以及水溶液中的精神分裂剂相行使表明它们在血液接触应用中的潜力。

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  • 来源
    《Biomacromolecules》 |2012年第9期|共10页
  • 作者

    Yu-Ju Shih; Andre Deratani; Yung Chang;

  • 作者单位

    R&

    D Center for Membrane Technology and Department of Chemical Engineering Chung Yuan Christian University Jhong-Li Taoyuan 320 Taiwan;

    Institut Europeen des Membranes UMR S635 (CNRS-ENSCM-UM2) Universite Montpellier 2 Place E. Bataillon F- 3409S Montpellier France;

    R&

    D Center for Membrane Technology and Department of Chemical Engineering Chung Yuan Christian University Jhong-Li Taoyuan 320 Taiwan;

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  • 正文语种 eng
  • 中图分类 分子生物学;
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