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首页> 外文期刊>Acta biomaterialia >Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging
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Development of europium doped core-shell silica cobalt ferrite functionalized nanoparticles for magnetic resonance imaging

机译：开发铕掺杂芯壳二氧化硅钴铁氧体官能化纳米粒子用于磁共振成像

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摘要

The size, shape and chemical composition of europium (Eu3+) cobalt ferrite (CFEu) nanoparticles were optimized for use as a "multimodal imaging nanoprobe" for combined fluorescence and magnetic resonance bioimaging. Doping Eu3+ ions into a CF structure imparts unique bioimaging and magnetic properties to the nanostructure that can be used for real-time screening of targeted nanoformulations for tissue biodistribution assessment. The CFEu nanoparticles (size similar to 7.2 nm) were prepared by solvothermal techniques and encapsulated into poloxamer 407-coated mesoporous silica (Si-P407) to form superparamagnetic monodisperse Si-CFEu nanoparticles with a size of similar to 140 nm. Folic acid (FA) nanoparticle decoration (FA-Si-CFEu, size similar to 140 nm) facilitated monocyte-derived macrophage (MDM) targeting. FA-Si-CFEu MDM uptake and retention was higher than seen with Si-CFEu nanoparticles. The transverse relaxivity of both Si-CFEu and FA-Si-CFEu particles were r(2) = 433.42 mM(-1) s(-1) and r(2) = 419.52 mM(-1) s(-1) (in saline) and r(2) = 736.57 mM(-1) s(-1) and r(2) = 814.41 mM(-1) s-1 (in MDM), respectively. The results were greater than a log order-of-magnitude than what was observed at replicate iron concentrations for ultra small superparamagnetic iron oxide (USPIO) particles (r(2) = 31.15 mM(-1) s(-1) in saline) and paralleled data sets obtained for T-2 magnetic resonance imaging. We now provide a developmental opportunity to employ these novel particles for theranostic drug distribution and efficacy evaluations.
机译：优化了铕（EU3 +）钴铁氧体（CFEU）纳米粒子（CFEU）纳米粒子的尺寸，形状和化学成分，用作“多模式成像纳米骨骨”，用于组合荧光和磁共振。将Eu3 +离子掺杂到CF结构中赋予纳米结构独特的生物分析和磁性，可用于用于组织生物分布评估的靶向纳米族种类的实时筛选。通过溶剂温技术制备CFEU纳米颗粒（尺寸与7.2nm类似），并将其包封成泊洛沙姆407-涂覆的介孔二氧化硅（Si-P407），以形成具有相似与140nm的尺寸的超顺磁性单分散Si-CFEU纳米颗粒。叶酸（Fa）纳米粒子装饰（Fa-Si-CFEU，尺寸类似于140nm），促进了单核细胞衍生的巨噬细胞（MDM）靶向。 FA-Si-CFEU MDM吸收和保留高于Si-CFEU纳米粒子。 Si-CFEU和FA-Si-CFEU颗粒的横向松弛率为R（2）= 433.42mm（-1）S（-1）和R（2）= 419.52mm（-1）s（-1）（在盐水中，r（2）= 736.57mm（-1）s（-1）s（-1）和r（2）= 814.41mm（-1）s-1（mdm）。结果大于数级数量，而不是以超小型超顺氧化铁（USPIO）颗粒（R（2）= 31.15mm（-1）S（-1）S（-1）S（-1）S（-1）S（-1）S（-1）s（-1）S（-1）S（-1）（-1）））为T-2磁共振成像获得的并行数据集。我们现在提供了雇用这些新颗粒用于治疗药物分布和疗效评估的发展机会。

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