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首页> 外文期刊>Acta biomaterialia >SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening
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SIRT1 protects osteoblasts against particle-induced inflammatory responses and apoptosis in aseptic prosthesis loosening

机译：SIRT1保护骨细胞免受粒子诱导的炎症反应和无菌假体松开的凋亡

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摘要

We hypothesized that SIRT1 downregulation in osteoblasts induced by wear particles was one of the reasons for particle-induced osteolysis (PIO) in total joint arthroplasty failure. In the present study, the expression of SIRT1 was examined in osteoblasts treated with TiAl6V4 particles (Ties) and CoCrMo particles (Cops) from materials used in prosthetics and specimens from PIO animal models. To address whether SIRT1 downregulation triggers inflammatory responses and apoptosis in osteoblasts, the effect of a SIRT1 activator, resveratrol on the expression of inflammatory cytokines and apoptosis in particle treated osteoblasts was tested. The results demonstrated that SIRT1 expression was significantly down regulated in particle-treated osteoblasts and PIO animal models. Both pharmacological activation and overexpression of SIRT1 dramatically reduced the particle-induced expression of inflammatory cytokines and osteoblast apoptosis through NE-kappa B and p53 signaling, respectively. Furthermore, in PIO animal models, resveratrol significantly reduced the severity of osteolysis. Collectively, the results of the present study indicated that SIRT1 plays a vital role in the pathogenesis of aseptic loosening, and further treatment targeted at SIRT1 possibly lead to novel approaches for prevention of aseptic prosthesis loosening.
机译：我们假设由磨损颗粒诱导的成骨细胞中的SIRT1下调是颗粒诱导的溶血性关节成形术失败的原因之一。在本研究中，在用Pio动物模型中使用的TiAl6v4颗粒（TiEs）和CoCroMo颗粒（COP）处理的成骨细胞中SIRT1的表达。为了解决中下调瘙痒症是否触发炎症反应和在成骨细胞中的炎性反应和凋亡，测试了SIRT1活化剂，白藜芦醇对颗粒处理的成骨细胞表达和凋亡的凋亡的作用。结果表明，在颗粒处理的成骨细胞和PIO动物模型中，SIRT1表达显着下降。 SIRT1的药理学活化和过表达分别通过NE-Kappa B和P53信号传导显着降低了颗粒诱导的炎性细胞因子和成骨细胞凋亡的表达。此外，在Pio动物模型中，白藜芦醇显着降低了骨解的严重程度。集体，本研究结果表明，SIRT1在无菌松动的发病机制中起着至关重要的作用，并且在SIRT1靶向的进一步治疗可能导致预防无菌假体松动的新方法。

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  • 来源
    《Acta biomaterialia》 |2017年第2017期|共14页
  • 作者

    Deng Zhantao; Wang Zhenheng; Jin Jiewen; Wang Yong; Bao Nirong; Gao Qian; Zhao Jianning;

  • 作者单位

    Nanjing Univ Sch Med Jinling Hosp Dept Orthoped 305 Zhongshan East Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Sch Med Jinling Hosp Dept Orthoped 305 Zhongshan East Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Ctr Translat Med Sch Med Nanjing Jiangsu Peoples R China;

    Nanjing Univ Ctr Translat Med Sch Med Nanjing Jiangsu Peoples R China;

    Nanjing Univ Sch Med Jinling Hosp Dept Orthoped 305 Zhongshan East Rd Nanjing 210002 Jiangsu;

    Nanjing Univ Ctr Translat Med Sch Med Nanjing Jiangsu Peoples R China;

    Nanjing Univ Sch Med Jinling Hosp Dept Orthoped 305 Zhongshan East Rd Nanjing 210002 Jiangsu;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    SIRT1; Osteoblast; Inflammatory responses; Apoptosis; Osteolysis; Aseptic loosening;

    机译：sirt1;成骨细胞;炎症反应;细胞凋亡;骨溶解;无菌松动;

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