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首页> 外文期刊>Acta biomaterialia >Additively manufactured metallic porous biomaterials based on minimal surfaces: A unique combination of topological, mechanical, and mass transport properties
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Additively manufactured metallic porous biomaterials based on minimal surfaces: A unique combination of topological, mechanical, and mass transport properties

机译：基于最小表面的碱性制造的金属多孔生物材料：拓扑，机械和大规模运输性能的独特组合

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Porous biomaterials that simultaneously mimic the topological, mechanical, and mass transport properties of bone are in great demand but are rarely found in the literature. In this study, we rationally designed and additively manufactured (AM) porous metallic biomaterials based on four different types of triply periodic minimal surfaces (TPMS) that mimic the properties of bone to an unprecedented level of multi-physics detail. Sixteen different types of porous biomaterials were rationally designed and fabricated using selective laser melting (SLM) from a titanium alloy (Ti-6Al-4V). The topology, quasi-static mechanical properties, fatigue resistance, and permeability of the developed biomaterials were then characterized. In terms of topology, the biomaterials resembled the morphological properties of trabecular bone including mean surface curvatures close to zero. The biomaterials showed a favorable but rare combination of relatively low elastic properties in the range of those observed for trabecular bone and high yield strengths exceeding those reported for cortical bone. This combination allows for simultaneously avoiding stress shielding, while providing ample mechanical support for bone tissue regeneration and osseointegration. Furthermore, as opposed to other AM porous biomaterials developed to date for which the fatigue endurance limit has been found to be of their yield (or plateau) stress, some of the biomaterials developed in the current study show extremely high fatigue resistance with endurance limits up to 60% of their yield stress. It was also found that the permeability values measured for the developed biomaterials were in the range of values reported for trabecular bone. In summary, the developed porous metallic biomaterials based on TPMS mimic the topological, mechanical, and physical properties of trabecular bone to a great degree. These properties make them potential candidates to be applied as parts of orthopedic implants and/or as bone-substituting biomaterials.
机译：同时模拟骨质，机械和大规模运输性能的多孔生物材料是大需求，但很少在文献中发现。在这项研究中，我们基于四种不同类型的三个不同类型的三种周期性最小表面（TPMS）来理性地设计和加剧地制造（AM）多孔金属生物材料（TPMS），其模仿骨骼的性质到前所未有的多物理细节水平。使用来自钛合金（Ti-6Al-4V）的选择性激光熔融（SLM）合理地设计和制造了16种不同类型的多孔生物材料。然后表征了拓扑，准静态机械性能，疲劳性和抗疲劳性和渗透性。在拓扑方面，生物材料类似于小梁骨的形态学性质，包括平均表面曲率接近零。生物材料显示出良好但罕见的相对较低的弹性特性的组合，其在观察到用于小梁骨的高屈服强度超过报告的皮质骨的高屈服强度。这种组合允许同时避免应力屏蔽，同时提供对骨组织再生和骨整合的充分机械支撑。此外，与迄今为止发现疲劳耐久性限制的其他am多孔生物材料相反，目前研究中开发的一些生物材料显示出极高的疲劳性，耐久性限制占产量应激的60％。还发现对发育生物材料测量的渗透率值是针对小梁骨的值的值。总之，基于TPMS的开发的多孔金属生物材料模拟了小梁骨的拓扑，机械和物理性质至大程度。这些性质使其成为潜在的候选者作为骨科植入物和/或骨代替生物材料的部分。

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