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首页> 外文期刊>Acta biomaterialia >Cyclodextrin modified PLLA parietal reinforcement implant with prolonged antibacterial activity
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Cyclodextrin modified PLLA parietal reinforcement implant with prolonged antibacterial activity

机译：环糊精改性PLLA抗菌活性植入物植入物

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摘要

The use of textile meshes in hernia repair is widespread in visceral surgery. Though, mesh infection is a complication that may prolong the patient recovery period and consequently presents an impact on public health economy. Such concern can be avoided thanks to a local and extended antibiotic release on the operative site. In recent developments, poly-L-lactic acid (PLLA) has been used in complement of polyethyleneterephthalate (Dacron) (PET) or polypropylene (PP) yarns in the manufacture of semi-resorbable parietal implants. The goal of the present study consisted in assigning drug reservoir properties and prolonged antibacterial effect to a 100% PLLA knit through its functionalization with a cyclodextrin polymer (polyCD) and activation with ciprofloxacin. The study focused i) on the control of degree of polyCD functionalization of the PLLA support and on its physical and biological characterization by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC) and cell viability, ii) on the understanding of drug/meshes interaction using mathematic model and iii) on the correlation between drug release studies in phosphate buffer saline (PBS) and microbiological evaluation of meshes and release medium against E. coli and S. aureus. All above mentioned tests highlighted the contribution of polyCD on the improved performances of the resulting antibacterial implantable material.
机译：在疝气修复中使用纺织网格在内脏手术中普遍存在。虽然，网眼感染是可能延长患者恢复期的并发症，从而对公共卫生经济带来了影响。由于手术部位上的局部和扩展抗生素释放，可以避免这种担忧。在最近的发展中，在制造半可再吸收的椎管植入物中，聚-L-乳酸（PLLA）已被用于补蛋白（涤纶）（PET）或聚丙烯（PP）纱线。本研究的目的是通过用环糊精聚合物（PolyCD）的官能化并用环二氟甲酰辛激活来分配药物储层性能和延长抗菌作用，并通过其官能化并活化。该研究重点是通过扫描电子显微镜（SEM），差示扫描量热法（DSC）和细胞活力，II）对药物/差异扫描量（SEM），II）对PLLA支持的多元官能化程度的控制和其物理和生物学特性的控制。使用数学模型的相互作用和III）对磷酸盐缓冲盐水（PBS）的药物释放研究的相关性和对大肠杆菌和金黄色葡萄球菌的粘合剂和释放培养基的微生物学评价。所有上述测试都突出了PolyCd对所得抗菌可植入材料的改进性能的贡献。

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