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首页> 外文期刊>Acta biomaterialia >Cytotoxicity of gold nanoparticles with different structures and surface-anchored chiral polymers
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Cytotoxicity of gold nanoparticles with different structures and surface-anchored chiral polymers

机译：金纳米颗粒具有不同结构和表面锚固手性聚合物的细胞毒性

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Nanoparticles (NPs) can have profound effects on cell biology. However, the potential adverse effects of gold nanoparticles (AuNPs) with different surface chirality and structures have not been elucidated. In this study, monolayers of poly(acryloyl-L(D)-valine (L(D)-PAV) chiral molecules were anchored on the surfaces of gold nanocubes (AuNCs) and nanooctahedras (AuNOs), respectively. The L-PAV-AuNCs and D-PAV-AuNCs, or the L-PAV-AuNOs and D-PAV-AuNOs, had identical physicochemical properties in terms of size, morphology and ligand density except of the reverse molecular chirality on the particle surfaces, respectively. The L-PAV capped AuNCs and AuNOs exhibited larger cytotoxicity to A549 cells than the D-PAV coated ones, and the PAV-AuNOs had larger cytotoxicity than PAV-AuNCs when being capped with the same type of enantiomers, respectively. The cytotoxicity was positively correlated with the cellular uptake amount, and thereby the production of intracellular reactive oxygen species (ROS).
机译：纳米颗粒（NPS）可以对细胞生物学产生深远的影响。然而，尚未阐明金纳米颗粒（AUNP）与不同表面手平性和结构的潜在不利影响。在该研究中，聚（Acryloyl-L（D） - 缬氨酸（L（d）-pav）手性分子的单层分别分别锚定在金纳米孔（aunc）和纳米藻菌（aunos）的表面上。L-PAV- auncs和d-pav-auncs或l-pav-aunos和d-pav-aunos，在尺寸，形态和配体密度方面具有相同的物理化学性质，除了颗粒表面上的逆分分子培养性。升-pav paved auncs和auncs和aunos表现出比d-pav涂层的细胞毒性更大的细胞毒性，并且当用相同类型的对映体的封装时，pav-aunos具有比pav-auncs更大的细胞毒性。细胞毒性正相关细胞吸收量，从而产生细胞内反应性氧（ROS）。

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