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首页> 外文期刊>Acta biomaterialia >Biodegradable inorganic-organic hybrids of methacrylate star polymers for bone regeneration
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Biodegradable inorganic-organic hybrids of methacrylate star polymers for bone regeneration

机译：用于骨再生的甲基丙烯酸酯星聚合物的可生物降解的无机有机杂种

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Hybrids that are molecular scale co-networks of organic and inorganic components are promising biomaterials, improving the brittleness of bioactive glass and the strength of polymers. Methacrylate polymers have high potential as the organic source for hybrids since they can be produced, through controlled polymerization, with sophisticated polymer architectures that can bond to silicate networks. Previous studies showed the mechanical properties of hybrids can be modified by polymer architecture and molar mass (MM). However, biodegradability is critical if hybrids are to be used as tissue engineering scaffolds, since the templates must be remodelled by host tissue. Degradation by-products have to either completely biodegrade or be excreted by the kidneys. Enzyme, or bio-degradation is preferred to hydrolysis by water uptake as it is expected to give a more controlled degradation rate. Here, branched and star shaped poly (methyl methacrylate-co-3-(trimethoxysilyl)propyl methacrylate) (poly(MMA-co-TMSPMA)) were synthesized with disulphide based dimethacrylate (DSDMA) as a biodegradable branching agent. Biodegradability was confirmed by exposing the copolymers to glutathione, a tripeptide which is known to cleave disulphide bonds. Cleaved parts of the star polymer from the hybrid system were detected after 2 weeks of immersion in glutathione solution, and MM was under threshold of kidney filtration. The presence of the branching agent did not reduce the mechanical properties of the hybrids and bone progenitor cells attached on the hybrids in vitro. Incorporation of the DSDMA branching agent has opened more possibilities to design biodegradable methacrylate polymer based hybrids for regenerative medicine.
机译：杂交种是有机和无机组分的分子规模共同网络是有前途的生物材料，从而提高生物活性玻璃的脆性和聚合物的强度。甲基丙烯酸酯聚合物具有高潜力作为杂交种的有机源，因为它们可以通过控制聚合生产，具有可以粘合到硅酸盐网络的复杂的聚合物架构。以前的研究表明，杂种的机械性能可以通过聚合物结构和摩尔质量（mm）来改变。然而，如果将杂种用作组织工程支架，则生物降解性至关重要，因为模板必须被宿主组织重塑。降解副产物必须完全生物降解或被肾脏排出。酶，或生物降解优选通过水吸收的水解，因为预期产生更受控制的降解速率。这里，用基于二硫化物的二甲基丙烯酸酯（DSDMA）作为可生物降解的支化剂，合成了支链和星形聚（甲基丙烯酸甲酯-CO-3-（三甲氧基甲磺酸甲硅烷基）丙基丙酯）（聚（MMA-CO-TMSPMA）），作为可生物降解的支化剂。通过将共聚物暴露于谷胱甘肽，已知已知裂解二硫键的三肽来证实生物降解性。在谷胱甘肽溶液中浸泡2周后检测来自杂交系统的星形聚合物的切割部分，MM在肾脏过滤的阈值下。支化剂的存在未降低在体外附着在杂种上的杂种和骨祖细胞的机械性能。掺入DSDMA分支剂对更多的可能性来设计用于再生医学的可生物降解的甲基丙烯酸酯聚合物的杂种。

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