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首页> 外文期刊>Acta biomaterialia >Optical imaging and anticancer chemotherapy through carbon dot created hollow mesoporous silica nanoparticles
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Optical imaging and anticancer chemotherapy through carbon dot created hollow mesoporous silica nanoparticles

机译：光学成像和抗癌化疗通过碳点产生中空介孔二氧化硅纳米粒子

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摘要

Multifunctional nanocarrier-based theranostics is currently considered to solve some key unmet challenges in cancer treatment. Here we report a nanocarrier platform, named carbon dot (CD) created mesoporous hollow organosilica (C-hMOS) nanoparticles, to deliver anticancer drug and to enable optical imaging. The hollow structure was formed by the removal of a nanorod core template, and at the same time, the fluorescent signal was endowed from the heat-treated organosilica network. Thanks to the hollow and mesoporous structure, the C-hMOS effectively loaded doxorubicin (DOX) for cancer chemotherapy. The DOX was released from C-hMOS highly sustainably (over 12 days) and pH-dependently (pH 5.0 > pH 7.4). The DOX-loading C-hMOS internalized cancer cells efficiently (>90%), and induced cellular apoptosis including the expression of caspase-3. The treatment of C-hMOS to cancer cells enabled multi-color visualization in vitro, suggesting the possibility of cell tracing. Moreover, when injected intratumorally in mice, the C-hMOS exhibited strong optical signals in vivo along with a high optical stability (over a week). The injected C-hMOS were distributed only a fraction in liver but not in heart, lung, spleen or kidney and displayed good biocompatibility. The DOX-delivering C-hMOS significantly suppressed the in vivo tumor growth associated with apoptotic functions. Taken together, the developed C-hMOS nanoparticles can be a promising nanoplatform for drug delivery and in vivo imaging in cancer treatment.
机译：目前认为多功能纳米载载体的Theranostics在癌症治疗中解决了一些关键的未满足挑战。在这里，我们报告了一个名为碳点（CD）的纳米载波平台，所述碳点（CD）产生了介孔中空有机硅藻（C-HMOS）纳米颗粒，以递送抗癌药物并能够实现光学成像。通过除去纳米棒芯模板形成中空结构，同时，荧光信号从热处理的有机硅网络中赋予。由于空心和中孔结构，C-HMOS有效地为癌症化疗有效地装载了多柔比星（DOX）。 DOX从C-HMOS高度可持续（超过12天）和pH依赖性（pH 5.0> pH 7.4）从C-HMOS释放。 Dox加载C-HMOS内化癌细胞有效（> 90％），并诱导包括Caspase-3表达的细胞凋亡。将C-HMOS治疗对癌细胞的体外具有多色可视化，表明细胞跟踪的可能性。此外，当在小鼠中注射涉及的睫状体中，C-HMO在体内表现出强光信号以及高光学稳定性（一周）。注射的C-HMOS仅在肝脏中分布，但不在心脏，肺，脾脏或肾脏中分布，并显示出良好的生物相容性。 DOX提供的C-HMOS显着抑制了与凋亡功能相关的体内肿瘤生长。连同，开发的C-HMOS纳米粒子可以是用于药物递送和癌症治疗中的体内成像的有前途的纳米粒状。

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