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首页> 外文期刊>Acta biomaterialia >Lipogels responsive to near-infrared light for the triggered release of therapeutic agents
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Lipogels responsive to near-infrared light for the triggered release of therapeutic agents

机译：对治疗剂的触发释放的近红外光响应于近红外光

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Graphical abstract Display Omitted Abstract Here we report a composite system based on fibrin hydrogels that incorporate in their structure near-infrared (NIR) responsive nanomaterials and thermosensitive liposomes (TSL). Polymerized fibrin networks entrap simultaneously gold-based nanoparticles (NPs) capable of transducing NIR photon energy into heat, and lysolipid-incorporated TSL (LTSL) loaded with doxorubicin hydrochloride (DOX). NIR irradiation of the resulting hydrogels (referred to as “lipogels”) with 808 nm laser light increased the temperature of the illuminated areas, leading to the release of the liposomal cargo. Levels of DOX that release from the “smart” composites were dependent on the concentration of NIR nanotransducers loaded in the lipogel, the intensity of the electromagnetic energy deposited and the irradiation regime. Released DOX retained its bioactivity, as shown in cultures of epithelial carcinoma cells. Finally, the developed drug delivery platform was refined by using NIR-photoabsorbers based on copper sulfide NPs to generate completely biodegradable composites as well as through the incorporation of cholesterol (Ch) in LTSL formulation, which lessens leakiness of the liposomal cargo at physiological temperature. This remotely controlled system may suit well for those therapies that require precise control over the dose of delivered drug in a defined spatiotemporal framework. Statement of Significance Hydrogels composed of fibrin embedding nanoparticles responsive to near infrared (NIR) energy and thermosensitive liposomes loaded with doxorubicin hydrochloride (DOX), were prepared by in situ polymerization. NIR-light irradiation of these constructs, referred to as “NIR responsive lipogels”, results in the controlled release of DOX to the surrounding medium. This technology may use fully degradable components and can preserve the bioactivity of liposomal cargo after remote triggering to finely regulate the dose and bioavailability of delivered payloads. NIR responsive lipogels technology overcomes the limitations of drug release systems based on the combination of liposomes and degradable polymeric materials, which in many cases lead to insufficient release at therapy onset or to overdose during high degradation period. ]]>
机译：在此省略了图形的抽象显示，我们在此报告基于纤维蛋白水凝胶的复合系统，其在其结构中近红外（NIR）响应性纳米材料和热敏脂质体（TSL）。聚合的纤维蛋白网络诱捕同时的金基纳米颗粒（NPS）能够将NIR光子能量转换成热量，并掺入盐酸多柔比星（DOX）的Lysolipid掺入TSL（LTS1）。产生的水凝胶的鼻辐射（称为“Lipogels”），808nm激光增加了照明区域的温度，导致脂质体载体的释放。从“智能”复合材料中释放的DOX水平依赖于Lipogel中装载的Nir纳米转搅拌器的浓度，电磁能量沉积的强度和辐照制度。释放DOX保留其生物活性，如上皮癌细胞的培养物所示。最后，通过基于硫化铜NPS使用NIR-PHOCKABSORGER来改进发育的药物输送平台，以产生完全可生物降解的复合材料，以及在LTS1制剂中掺入胆固醇（CH），其在生理温度下减少脂质体货物的泄漏。这种远程控制的系统适用于需要在定义的时空框架中对递送的药物剂量进行精确控制的疗法。通过原位聚合制备由响应于近红外（NIR）能量和热敏脂质体的纤维蛋白嵌入纳米颗粒组成的显着性水凝胶陈述通过原位聚合制备。这些构建体的NIR光照射，称为“NIR响应性脂肪凝胶”，导致DOX对周围介质的控制释放。该技术可以使用完全可降解的组分，并且在远程触发以精细调节输送有效载荷的剂量和生物利用性后，可以保持脂质体货物的生物活性。 NIR响应性LipoGels技术克服了基于脂质体和可降解聚合物材料的组合的药物释放系统的局限性，在许多情况下，在许多情况下导致治疗发生在治疗期间的释放不足或在高降解期间过量。 ]]>

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