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首页> 外文期刊>Acta biomaterialia >Linking multiscale deformation to microstructure in cortical bone using in-situ loading, digital image correlation and synchrotron X-ray scattering
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Linking multiscale deformation to microstructure in cortical bone using in-situ loading, digital image correlation and synchrotron X-ray scattering

机译：使用原位加载，数字图像相关性和同步X射线散射将多尺度变形与皮质骨中的微观结构联系起来

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摘要

The incidence of fragility fractures is expected to increase in the near future due to an aging population. Therefore, improved tools for fracture prediction are required to treat and prevent these injuries efficiently. For such tools to succeed, a better understanding of the deformation mechanisms in bone over different length scales is needed. In this study, an experimental setup including mechanical tensile testing in combination with digital image correlation (DIC) and small/wide angle X-ray scattering (SAXS/WAXS) was used to study deformation at multiple length scales in bovine cortical bone. Furthermore, micro-CT imaging provided detailed information about tissue microstructure. The combination of these techniques enabled measurements of local deformations at the tissue- and nanoscales. The orientation of the microstructure relative to the tensile loading was found to influence the strain magnitude on all length scales. Strains in the collagen fibers were 2-3 times as high as the strains found in the mineral crystals for samples with microstructure oriented parallel to the loading. The local tissue strain at fracture was found to be around 0.5%, independent of tissue orientation. However, the maximum force and the irregularity of the crack path were higher when the load was applied parallel to the tissue orientation. This study clearly shows the potential of combining these different experimental techniques concurrently with mechanical testing to gain a better understanding of bone damage and fracture over multiple length scales in cortical bone.
机译：由于人口老龄化，预计脆弱性骨折的发生率将在不久的将来增加。因此，有效地需要改进的裂缝预测工具来治疗和防止这些伤害。对于这样的工具来说，需要更好地理解在不同长度尺度上的骨骼中的变形机制。在该研究中，使用包括与数字图像相关（DIC）和小/宽角X射线散射（SAXS /蜡）组合的机械拉伸测试的实验装置用于研究牛皮质骨中的多个长度尺度的变形。此外，微型CT成像提供了有关组织微观结构的详细信息。这些技术的组合能够在组织和纳米粒子下能够测量局部变形。发现相对于拉伸载荷的微观结构的取向来影响所有长度尺度的应变幅度。胶原纤维中的菌株与矿物晶体中的菌株相比的菌株为2-3倍，用于与加载平行的微观结构定向的样品。骨折处的局部组织菌株被发现约为0.5％，与组织取向无关。然而，当负载平行于组织取向时，裂缝路径的最大力和不规则性更高。该研究清楚地表明了将这些不同的实验技术同时与机械测试相结合的可能性，以更好地了解皮质骨中多个长度鳞片上的骨损伤和骨折。

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