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首页> 外文期刊>Acta biomaterialia >Transplantation of autologous oral mucosal epithelial cell sheets inhibits the development of acquired external auditory canal atresia in a rabbit model
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Transplantation of autologous oral mucosal epithelial cell sheets inhibits the development of acquired external auditory canal atresia in a rabbit model

机译：自体口腔粘膜上皮细胞片的移植抑制了兔模型中所获得的外耳道闭锁的发展

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摘要

Acquired external auditory canal atresia is characterized by fibrous tissue formation in the ear canal, hearing loss and chronic otorrhea. Although the disease can be treated surgically, the recurrence rate is high. This study explored whether autologous oral mucosal epithelial cell sheets could be used as a novel therapy for ear canal atresia. We succeeded in generating a rabbit model of acquired external auditory canal atresia by dissecting the skin of the ear canal. Endoscopic and histological findings in this model indicated that atresia developed over a 4-week period and was not inhibited by the placement of polyglycolic acid sheets immediately after skin dissection. By contrast, transplantation of autologous oral mucosal epithelial cell sheets, which had been fabricated by culture on temperature-responsive inserts without a feeder layer, prevented the development of atresia during the 4-week period after skin dissection. Transplantation of autologous epithelial cell sheets after surgical treatment of acquired external auditory canal atresia could be a promising new method to reduce the risk of disease recurrence.
机译：获得的外耳道闭锁是耳道中纤维组织形成的特征，听力丧失和慢性耳细胞。虽然该疾病可以手术治疗，但复发率高。本研究探讨了自体口腔粘膜上皮细胞片是否可用作耳道闭锁的新疗法。通过解剖耳道的皮肤，我们成功地产生了所获得的外耳道闭锁的兔子模型。该模型中的内窥镜和组织学发现表明，休息时间在4周的时间内开发，并且在皮肤分析后立即放置聚乙醇片的抑制。相比之下，通过在没有饲养层的温度响应插入物上通过培养物制造的自体口腔粘膜上皮细胞片的移植，防止了在皮肤分析后4周的时间内发生闭锁。自体上皮细胞片外移植在收购外耳道的外科治疗后，可能是降低疾病复发风险的有希望的新方法。

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