• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Characterization of calcium phosphate cements modified by addition of amorphous calcium phosphate.
【24h】

Characterization of calcium phosphate cements modified by addition of amorphous calcium phosphate.

机译：通过添加非晶磷酸钙改性磷酸钙水泥的表征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In this study the influence of amorphous calcium phosphate (ACP) on the setting of, and the formed apatite crystallite size in, a calcium phosphate cement (CPC) based on alpha-tricalcium phosphate (alpha-TCP) or tetracalcium phosphate (TTCP)/monocalcium phosphate monohydrate (MCPM) was investigated. Setting times at 22 degrees C were measured in air atmosphere; those at 37 degrees C were measured at 100% relative humidity. The phase composition of the set cements was investigated after 1 week using X-ray diffractometry and infrared spectroscopy and the morphology was investigated using scanning electron microscopy. The compressive strength (CS) of the set CPCs was measured after 1 day. Viability of MC3T3-E1 cells on the CPCs was analyzed after 7, 14 and 21 days of incubation using the CellTiter 96 Aqueous Non-Radioactive Cell Proliferation Assay. The alpha-TCP-based cement exhibited long setting times, a high CS and was converted to a calcium-deficient hydroxyapatite (CDHAp). The TTCP/MCPM-based CPC was only partly converted to CDHAp, produced acceptable setting times and had a low CS. Addition of ACP to these two CPCs resulted in cements that exhibited good setting times, CS suitable for non-load-bearing applications and a full conversion to nanocrystalline CDHAp. Moreover, the ACP containing CPCs demonstrated good cell viability, making them suitable candidates for bone substitute materials.
机译：在该研究中，基于磷酸钙（α-TCP）或磷酸氢钙（TTCP）/研究了磷酸二钙一水合物（MCPM）。在空气气氛中测量22摄氏度的设定时间;在100％相对湿度下测量37℃时的那些。使用X射线衍射法和红外光谱检查1周后研究设定水泥的相组合物，并使用扫描电子显微镜研究了形态。在1天后测量组CPC的压缩强度（CS）。使用Celltiter 96含水非放射性细胞增殖测定孵育的7,14和21天后分析CPC上MC3T3-E1细胞的活力。基于α-TCP的水泥显示出长度的次数，高Cs，并转化为缺乏羟基磷灰石（CDHAP）。基于TTCP / MCPM的CPC仅部分地转换为CDHAP，产生可接受的设置时间并具有低CS。向这两个CPC添加ACP导致水泥显示出良好的设定时间，CS适用于非承载应用和全面转化为纳米晶CDHAP。此外，含有CPC的ACP展示了良好的细胞活力，使其适用于骨替代材料的候选物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号