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首页> 外文期刊>Acta biomaterialia >A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: In vitro and in vivo studies
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A pure zinc membrane with degradability and osteogenesis promotion for guided bone regeneration: In vitro and in vivo studies

机译：一种纯锌膜，具有可降解性和骨开发促进引导骨再生：体外和体内研究

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Selection of an appropriate membrane material for guided bone regeneration (GBR) is still ongoing among resorbable and nonresorbable membranes with different characteristics. The major problem with nonresorbable membranes is the inevitable secondary surgery, while resorbable polymer membranes have limitations in providing sufficient mechanical support during the bone repair period due to premature loss of mechanical strength. Pure magnesium foil has been evaluated to explore its feasibility as a resorbable GBR membrane. It exhibited better mechanical properties, whereas poor formability and fast degradation rate were noted. In light of this, pure zinc membrane was developed as a pilot research in this paper. We designed three types of pure zinc membranes: pure Zn without pores, pure Zn with 300 pm diameter and 1000 pm diameter pores, and pure titanium without pores as a control. The mechanical property, in vitro immersion tests, and MC3T3-E1 cell viability assays were tested. Moreover, in vivo behaviors of three type zinc membranes were evaluated by using a rat calvarial critical-sized bone defect model. The experimental results indicated that pure Zn membrane with 300 pm pores showed the most favorable osteogenic capability, comparable to that of titanium membrane without pores. Therefore, considering appropriate degradation rate, adequate mechanical maintenance, and profitable osteogenic capacity, metallic pure zinc is believed to be a promising candidate for barrier membranes in GBR therapy for bone regeneration, and its mechanical property can be enhanced with further alloying.
机译：用于引导骨再生（GBR）的适当膜材料在具有不同特征的可再吸收和不可吸收的膜中仍在进行。非可吸收膜的主要问题是不可避免的继发手术，而可再吸收的聚合物膜具有在骨修复期间提供足够的机械载体，由于机械强度过早损失。已经评估了纯镁箔以探讨其作为可再吸收的GBR膜的可行性。它表现出更好的机械性能，而易成形性和快速降解率较差。鉴于此，纯锌膜被开发为本文的试验研究。我们设计了三种类型的纯锌膜：纯Zn，无孔，纯锌，300pm直径和1000pm直径孔，和纯钛，没有孔的纯钛作为对照。测试机械性能，体外浸渍试验和MC3T3-E1细胞活力测定。此外，通过使用大鼠颅骨临界大小的骨缺损模型评估三种型锌膜的体内行为。实验结果表明，具有300μm孔隙的纯Zn膜显示出最有利的骨质化能力，与没有孔的钛膜相当。因此，考虑到适当的降解速率，充分的机械维持和有利可图的成骨容量，金属纯锌被认为是骨再生GBR疗法中的屏障膜的有希望的候选者，并且其机械性能可以通过进一步的合金化增强。

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