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首页> 外文期刊>Acta biomaterialia >Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia
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Electrophysiological-mechanical coupling in the neuronal membrane and its role in ultrasound neuromodulation and general anaesthesia

机译：神经元膜中的电生理 - 机械耦合及其在超声神经调节和全身麻醉中的作用

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摘要

The current understanding of the role of the cell membrane is in a state of flux. Recent experiments show that conventional models, considering only electrophysiological properties of a passive membrane, are incomplete. The neuronal membrane is an active structure with mechanical properties that modulate electrophysiology. Protein transport, lipid bilayer phase, membrane pressure and stiffness can all influence membrane capacitance and action potential propagation. A mounting body of evidence indicates that neuronal mechanics and electrophysiology are coupled, and together shape the membrane potential in tight coordination with other physical properties. In this review, we summarise recent updates concerning electrophysiological-mechanical coupling in neuronal function. In particular, we aim at making the link with two relevant yet often disconnected fields with strong clinical potential: the use of mechanical vibrations-ultrasound-to alter the electrophysiogical state of neurons, e.g., in neuromodulation, and the theories attempting to explain the action of general anaesthetics.
机译：目前对细胞膜作用的理解处于通量状态。最近的实验表明，考虑被动膜的电生理性质，常规模型是不完整的。神经元膜是一种活性结构，具有调节电生理学的机械性能。蛋白质传输，脂质双相相，膜压力和刚度都可以影响膜电容和动作电位繁殖。安装的证据主体表明神经元力学和电生理学偶联，并在与其他物理性质紧密配位中塑造膜电位。在本文中，我们总结了神经元功能中的电生理机械耦合的最近更新。特别是，我们的目的是与具有强大临床潜力的两个相关又有多个断开的领域的链接：利用机械振动 - 超声 - 改变神经元的电生理状态，例如在神经调节中，以及试图解释行动的理论一般麻醉药。

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