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首页> 外文期刊>Acta biomaterialia >Effect of addition of hyaluronic acids on the osteoconductivity and biodegradability of synthetic octacalcium phosphate
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Effect of addition of hyaluronic acids on the osteoconductivity and biodegradability of synthetic octacalcium phosphate

机译：透明质酸添加对磷酸盐骨骨导电性和生物降解性的影响

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摘要

The present study was designed to investigate whether three sodium hyaluronic acid (HyA) medical products, Artz?, Suvenyl? and a chemically modified derivative of sodium HyA Synvisc?, can be used as suitable vehicles for an osteoconductive octacalcium phosphate (OCP). OCP granules (300-500 μm diameter) were mixed with these sodium HyAs with molecular weights of 90 × 104 (Artz?), 190 × 104 (Suvenyl?) and 600 × 104 (Synvisc?) (referred to as HyA90, HyA190 and HyA600, respectively). OCP-HyA composites were injected using a syringe into a polytetrafluoroethylene ring, placed on the subperiosteal region of mouse calvaria for 3 and 6 weeks, and then bone formation was assessed by histomorphometry. The capacity of the HyAs for osteoclast formation from RAW264 cells with RANKL was examined by TRAP staining in vitro. Bone formation was enhanced by the OCP composites with HyA90 and HyA600, compared to OCP alone, through enhanced osteoclastic resorption of OCP. HyA90 and HyA600 facilitated in vitro osteoclast formation. The results suggest that the osteoconductive property of OCP was accelerated by the HyAs-associated osteoclastic resorption of OCP, and therefore that HyA/OCP composites are attractive bone substitutes which are injectable and bioactive materials.
机译：本研究旨在探讨三钠透明质酸（HYA）医疗产品，ARTZ吗？，抑郁症？和Hya Synvisc钠的化学改性衍生物，可用作骨干导电八氯钙（OCP）的合适车辆。将OCP颗粒（300-500μm直径）与这些肝脏混合，其中分子量为90×104（ARTZ？），190×104（抑郁症？）和600×104（SYNVISC？）（称为HYA90，HYA190和HYA600分别）。使用注射器注射到聚四氟乙烯环中的OCP-Hya复合物，置于小鼠Calvaria的亚脑膜区域3和6周，然后通过组织形态学评估骨形成。通过体外捕获染色捕获方法，从Raw264细胞中形成Hyas对Rap264细胞的骨壳形成的能力。通过同时通过增强OCP的骨细胞复合，通过HYA90和HYA600的OCP复合材料增强了骨形成。 HYA90和HYA600促进体外骨壳形成。结果表明，OCP的骨导电性通过OCP的相关性骨质体塑性再吸收加速，因此Hya / OCP复合材料是具有可注射和生物活性材料的吸引力的骨替代物。

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  • 来源
    《Acta biomaterialia》 |2014年第1期|共13页
  • 作者

    SuzukiK.; AnadaT.; MiyazakiT.; MiyatakeN.; HondaY.; KishimotoK.N.; HosakaM.; ImaizumiH.; ItoiE.; SuzukiO.;

  • 作者单位

    Department of Orthopaedic Surgery Tohoku University School of Medicine Sendai 980-8574 Japan;

    Division of Craniofacial Function Engineering Tohoku University Graduate School of Dentistry;

    Division of Craniofacial Function Engineering Tohoku University Graduate School of Dentistry;

    Tohoku Orthopaedic Clinic Sendai 981-3121 Japan;

    Division of Craniofacial Function Engineering Tohoku University Graduate School of Dentistry;

    Department of Orthopaedic Surgery Tohoku University School of Medicine Sendai 980-8574 Japan;

    Department of Orthopaedic Surgery Tohoku University School of Medicine Sendai 980-8574 Japan;

    Department of Orthopedic Surgery Osaki Citizen Hospital Osaki 989-6183 Japan;

    Department of Orthopaedic Surgery Tohoku University School of Medicine Sendai 980-8574 Japan;

    Division of Craniofacial Function Engineering Tohoku University Graduate School of Dentistry;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Biodegradation; Bone regeneration; Hyaluronan products; Injectability; Octacalcium phosphate;

    机译：生物降解;骨再生;透明质酸盐;可注射性;磷酸八花酸;

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