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首页> 外文期刊>Acta biomaterialia >Meshes in a mess: Mesenchymal stem cell-based therapies for soft tissue reinforcement
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Meshes in a mess: Mesenchymal stem cell-based therapies for soft tissue reinforcement

机译：一系列网状物：间充质干细胞的软组织增强疗法

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摘要

Surgical meshes are frequently used for the treatment of abdominal hernias, pelvic organ prolapse, and stress urinary incontinence. Though these meshes are designed for tissue reinforcement, many complications have been reported. Both differentiated cell- and mesenchymal stem cell-based therapies have become attractive tools to improve their biocompatibility and tissue integration, minimizing adverse inflammatory reactions. However, current studies are highly heterogeneous, making it difficult to establish comparisons between cell types or cell coating methodologies. Moreover, only a few studies have been performed in clinically relevant animal models, leading to contradictory results. Finally, a thorough understanding of the biological mechanisms of mesenchymal stem cells in the context of foreign body reaction is lacking. This review aims to summarize in vitro and in vivo studies involving the use of differentiated and mesenchymal stem cells in combination with surgical meshes. According to preclinical and clinical studies and considering the therapeutic potential of mesenchymal stem cells, it is expected that these cells will become valuable tools in the treatment of pathologies requiring tissue reinforcement.
机译：手术网格经常用于治疗腹部疝，盆腔器官脱垂和应激尿失禁。虽然这些网格被设计用于组织加固，但已经报道了许多并发症。分化的细胞和间充质干细胞的疗法都变成了有吸引力的工具，以改善其生物相容性和组织积分，最大限度地减少不良炎症反应。然而，目前的研究是高度异质的，使得难以在细胞类型或细胞涂层方法之间建立比较。此外，在临床相关的动物模型中仅进行了一些研究，导致矛盾的结果。最后，缺乏对异物反应背景下的间充质干细胞生物机制的透彻理解。该审查旨在总结体外和体内研究，涉及使用分化和间充质干细胞与外科网眼的组合使用。根据临床前和临床研究并考虑间充质干细胞的治疗潜力，预计这些细胞将成为治疗需要组织增强的病理学的有价值的工具。

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  • 来源
    《Acta biomaterialia》 |2019年第2019期|共15页
  • 作者

    Marinaro F.; Sanchez-Margallo F. M.; Alvarez V.; Lopez E.; Tarazona R.; Brun M. V.; Blazquez R.; Casado J. G.;

  • 作者单位

    Jesus Uson Minimally Invas Surg Ctr Stem Cell Therapy Unit Ctra N-521 Km 41-8 Caceres 10071;

    Jesus Uson Minimally Invas Surg Ctr Stem Cell Therapy Unit Ctra N-521 Km 41-8 Caceres 10071;

    Jesus Uson Minimally Invas Surg Ctr Stem Cell Therapy Unit Ctra N-521 Km 41-8 Caceres 10071;

    Jesus Uson Minimally Invas Surg Ctr Stem Cell Therapy Unit Ctra N-521 Km 41-8 Caceres 10071;

    Univ Extremadura Dept Physiol Immunol Unit Caceres 10071 Spain;

    Fed Univ Santa Maria UFSM Dept Small Anim Med Av Roraima 1000-7 Camobi BR-97105900 Santa Maria;

    Jesus Uson Minimally Invas Surg Ctr Stem Cell Therapy Unit Ctra N-521 Km 41-8 Caceres 10071;

    Jesus Uson Minimally Invas Surg Ctr Stem Cell Therapy Unit Ctra N-521 Km 41-8 Caceres 10071;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 普通生物学;
  • 关键词

    Surgical meshes; Mesenchymal stem cells; Foreign body reaction; Hernia;

    机译：外科网格;间充质干细胞;异物反应;疝气;

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