• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Structural changes in lipid mesophases due to intercalation of dendritic polymer nanoparticles: Swollen lamellae, suppressed curvature, and augmented structural disorder
【24h】

Structural changes in lipid mesophases due to intercalation of dendritic polymer nanoparticles: Swollen lamellae, suppressed curvature, and augmented structural disorder

机译：由于树突式聚合物纳米颗粒的插层而导致的脂质中间蛋白酶的结构变化：肿胀的薄片，抑制曲率和增强结构障碍

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Understanding interactions between nanoparticles and model membranes is relevant to functional nano-composites and the fundamentals of nanotoxicity. In this study, the effect of polyamidoamine (PAMAM) dendrimers as model nanoparticles (NP) on the mesophase behaviour of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE) has been investigated using high-pressure small-angle X-ray scattering (HP-SAXS). The pressure-temperature (p - T) diagrams for POPE mesophases in excess water were obtained in the absence and presence of G2 and G4 polyamidoamine (PAMAM) dendrimers (29 angstrom and 45 angstrom in diameter, respectively) at varying NP-lipid number ratio (nu = 0.0002-0.02) over the pressure range p = 1-3000 bar and temperature range T = 20-80 degrees C. The phase diagram of POPE exhibited the L-beta, L-alpha and H-II phases. Complete analysis of the phase diagrams, including the relative area pervaded by different phases, phase transition temperatures (T-t) and pressures (p(t)), the lattice parameters (d-spacing), the pressure-dependence of d-spacing (Delta d/Delta p), and the structural ordering in the mesophase as gauged by the Scherrer coherence length (L) permitted insights into the size- and concentration-dependent interactions between the dendrimers and the model membrane system. The addition of dendrimers changed the phase transition pressure and temperature and resulted in the emergence of highly swollen lamellar phases, dubbed L-beta-den and L alpha-den. G4 PAMAM dendrimers at the highest concentration nu = 0.02 suppressed the formation of the HII phase within the temperature range studied, whereas the addition of G2 PAMAM dendrimers at the same concentration promoted an extended mixed lamellar region in which L-alpha and L-beta phases coexisted.
机译：了解纳米颗粒和模型膜之间的相互作用与功能纳米复合材料和纳米毒性的基本原理相关。在该研究中，研究了聚酰胺胺（PAMAM）树枝状大分子作为模型纳米颗粒（NP）对1-PalmItoyl-2-Oleoyl-Sn-甘油-3-磷乙醇胺（POPE）的型号纳米粒子（NP）的影响已经使用高压小 - 角X射线散射（HP-SAXS）。在不同的NP-脂质值比以不同的NP-脂质值比的情况下，在不存在和存在下的G2和G4聚酰胺（PAMAM）树枝状大分子（PAMAM）树枝状大分子（PAMAM）树枝状大分子（PAMAM）树枝状大分子（29埃和45埃）的存在下获得过水中的压力 - 温度（P-T）图（Nu = 0.0002-0.02）在压力范围内P = 1-3000巴，温度范围T = 20-80℃。POPE的相图表明了L-β，L-α和H-II阶段。完全分析相图，包括由不同相位渗透的相对区域，相变温度（TT）和压力（P（T）），晶格参数（D-间距），D-间距的压力依赖性（Delta D / DELTA P）和中间相干长度（L）测量的中间相的结构排序允许洞察树枝状大分子和模型膜系统之间的尺寸和浓度依赖性相互作用。树枝状大分子的添加改变了相转变压力和温度，并导致高溶胀的层状阶段的出现，称为L-Beta-DEN和Lα-吲哚。在最高浓度Nu = 0.02处抑制了在所研究的温度范围内抑制了HiI相的形成，而在相同浓度下加入G2 Pamam树枝状体促进其中L-α和L-β相的延伸的混合层状区域共存。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号