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首页> 外文期刊>Acta biomaterialia >Self-assembling materials for therapeutic delivery.
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Self-assembling materials for therapeutic delivery.

机译：用于治疗递送的自组装材料。

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摘要

A growing number of medications must be administered through parenteral delivery, i.e., intravenous, intramuscular, or subcutaneous injection, to ensure effectiveness of the therapeutic. For some therapeutics, the use of delivery vehicles in conjunction with this delivery mechanism can improve drug efficacy and patient compliance. Macromolecular self-assembly has been exploited recently to engineer materials for the encapsulation and controlled delivery of therapeutics. Self-assembled materials offer the advantages of conventional crosslinked materials normally used for release, but also provide the ability to tailor specific bulk material properties, such as release profiles, at the molecular level via monomer design. As a result, the design of materials from the bottom up biomedical applications. This review provides an overview of self-assembling molecules, their resultant structures, and their use in therapeutic delivery. It highlights the current progress in the design of polymer- and peptide-based self-assembled materials.
机译：越来越多的药物必须通过肠胃外递送，即静脉内，肌肉内或皮下注射给药，以确保治疗的有效性。对于一些治疗方法，将递送载体与该递送机制结合使用可以改善药物疗效和患者依从性。最近已经利用了大分子自组装对封装和控制治疗的封装材料的工程。自组装材料提供通常用于释放的常规交联材料的优点，但还提供了通过单体设计在分子水平下定制特异性散装材料（例如释放曲线）的能力。结果，从底层生物医学应用中设计了材料。本综述概述了自组装分子，其所得结构及其在治疗递送方面的用途。它突出了基于聚合物和肽的自组装材料设计的目前的进展。

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