IFN-γ Colony-Stimulating Activity and In Vitro Effects on Neopterin Synthesis and Tryptophan Degradation

Y. Gluhcheva; E. Zvetkova; G. Konwalinka; D. Fuchs

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IFN-γ Colony-Stimulating Activity and In Vitro Effects on Neopterin Synthesis and Tryptophan Degradation

机译：IFN-γ集落刺激活性及其对新蝶呤合成和色氨酸降解的体外影响

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IFN-γ stimulated in vitro hematopoietic (erylhroid and myeloid) colony formation by cultured human CD34+ hematopoietic progenitor cells, as well as their neopterin production and tryptophan degradation. Elevated neopterin (NP) concentrations in the liquid layer of the semi-solid agar cultures corresponded to enhanced hematopoietic colony formation, decreased amounts of tryptophan (Try) and increased kynurenine concentrations. When the quantitative changes of both substances — neopterin and tryptophan, were compared, they showed linear statistical relation. Neopterin concentrations — compared to kynurenine/tryptophan ratio, gave exponential relation.

机译：IFN-γ通过培养的人CD34 +造血祖细胞刺激体外造血（类胡萝卜素和髓样）集落形成，以及新蝶呤和色氨酸的降解。半固体琼脂培养液层中新蝶呤（NP）浓度升高对应于造血集落形成增强，色氨酸（Try）含量降低和犬尿氨酸浓度升高。当比较两种物质新蝶呤和色氨酸的定量变化时，它们显示出线性统计关系。新蝶呤浓度-与犬尿氨酸/色氨酸之比相比，呈指数关系。

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《Acta morphologica et anthropologica》 |2008年第null期|共4页
作者
Y. Gluhcheva; E. Zvetkova; G. Konwalinka; D. Fuchs;
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正文语种 eng
中图分类细胞生物学;
关键词
human CD34+ hematopoietic progenitor cells; semi-solid agar cultures; IFN-γ; neopterin production; tryptophan degradation;

机译：人CD34 +造血祖细胞;半固态琼脂培养;IFN-γ;新蝶呤的产生;色氨酸降解;

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1. IFN-γ Colony-Stimulating Activity and In Vitro Effects on Neopterin Synthesis and Tryptophan Degradation [J] . Y. Gluhcheva, E. Zvetkova, G. Konwalinka, Acta morphologica et anthropologica . 2008,第Null期

机译：IFN-γ集落刺激活性及其对新蝶呤合成和色氨酸降解的体外影响
2. Delta9-tetrahydrocannabinol and cannabidiol modulate mitogen-induced tryptophan degradation and neopterin formation in peripheral blood mononuclear cells in vitro. [J] . Jenny M, Santer E, Pirich E Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2009,第1a2期

机译：Delta9-四氢大麻酚和大麻二酚在体外调节有丝分裂原诱导的色氨酸降解和新蝶呤在外周血单核细胞中的形成。
3. PADMA 28 modulates interferon-gamma-induced tryptophan degradation and neopterin production in human PBMC in vitro. [J] . Neurauter G, Wirleitner B, Schroecksnadel K, International immunopharmacology . 2004,第6期

机译：PADMA 28体外调节人PBMC中干扰素-γ诱导的色氨酸降解和新蝶呤的产生。
4. SYNTHESIS AND IN VITRO EFFECT OF PEPTIDES AND PEPTIDE-CONJUGATES FROM 16 kDa PROTEIN OF MYCOBACTERIUM TUBERCULOSIS ON IFN-γ PRODUCTION [C] . Kata Horvati, Szilvia Bosze, Gabor Mezo the European Peptide Symposium . 2007

机译：肽和肽 - 缀合物的合成及体外效应从结核分枝杆菌16 kDa蛋白对IFN-γ产生的影响
5. Part One. Synthesis of optically active tryptophan derivatives with potential activity as indoleamine 2,3-dioxygenase inhibitors: An approach via asymmetric catalytic hydrogenation. Part Two. Design, synthesis and pharmacology of selective ligands for alpha1-containing GABA(A)/benzodiazepine receptor subtypes: SAR studies of beta-carbolines at positions -3 and -6 and their corresponding bivalent ligands. Part Three. First enantiospecific total synthesis of the important biogenetic intermediates, (+)-polyneuridine and (+)-polyneuridine aldehyde, as well as 16-epi-vellosimine and macusine A. [D] . Yin, Wenyuan. 2007

机译：第一部分。具有吲哚胺2,3-二加氧酶抑制剂潜在活性的旋光色氨酸衍生物的合成：一种通过不对称催化氢化的方法。第二部分。含α1的GABA（A）/苯并二氮杂receptor受体亚型的选择性配体的设计，合成和药理作用：位于-3和-6位的β-咔啉及其相应的二价配体的SAR研究。第三部分。重要生物遗传中间体，（+）-聚神经氨酸和（+）-聚神经氨酸醛，以及16-表-维西辛和Macusine A的首次对映体全合成。
6. Phosphopyruvate carboxylase induction by l-tryptophan. Effects on synthesis and degradation of the enzyme [O] . F. J. Ballard, M. F. Hopgood 1973

机译：L-色氨酸诱导磷酸丙酮酸羧化酶。对酶的合成和降解的影响
7. In Vitro and In Vivo Effects of Granulocyte Colony-Stimulating Factor on Neutrophils in Glycogen Storage Disease Type IB: Granulocyte Colony-Stimulating Factor Therapy Corrects the Neutropenia and the Defects in Respiratory Burst Activity and Ca2+ Mobilization [O] . Lisa J Mccawley, Helen M Korchak, Steven D Douglas, 1994

机译：体外和体内肌肉细胞菌落刺激因子对糖原储存疾病型IB中子粒细胞的刺激因子：粒细胞菌落刺激因子疗法校正中性粒细胞率和呼吸爆发活性的缺陷和CA2 +动员

IFN-γ Colony-Stimulating Activity and In Vitro Effects on Neopterin Synthesis and Tryptophan Degradation

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