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首页> 外文期刊>Cytokine >Candidate gene case-control and functional study shows macrophage inhibitory factor (MIF) polymorphism is associated with cutaneous leishmaniasis
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Candidate gene case-control and functional study shows macrophage inhibitory factor (MIF) polymorphism is associated with cutaneous leishmaniasis

机译：候选基因病例对照和功能研究表明巨噬细胞抑制因子（MIF）多态性与皮肤LeishManiaisis相关

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摘要

American tegumentary leishmaniasis (ATL) is an infectious disease caused mostly by Leishmania(Viannia). braziliensis in Southeast Brazil. The clinical manifestations are vast, ranging from asymptomatic to severe mucosal leishmaniasis (ML). It has been suggested that variation of the pathogen does not fully explain the response spectrum and the variability of clinical manifestations. Previous data have shown that host genetics also play a role in disease outcome. Herein, we have tested the association of TNF, IL10, IL12 and MIF single nucleotide polymorphisms (SNPs) using a case-control study design including 110 cutaneous leishmaniasis (CL) patients and 682 healthy subjects. The genotype-phenotype correlation was also assessed using leishmania antigens to stimulate peripheral blood mononuclear cells obtained from cured CL patients. Results demonstrated that the MIF -173C allele is associated with leishmaniasis outcome and also with lower levels of MIF in culture supernatants. Also, the TNF -308AA genotype was statistically increased among leishmaniasis patients. The results showed here suggest that the lower levels of MIF produced by MIF -173C carriers could influence the host-Leishmania interaction, favoring infection and disease progression. On the other hand, high TNF levels can contribute to tissue damage, consequently leading to skin lesions.
机译：美国Tegumentary Leishmaniaisis（ATL）是一种主要由Leishmania（Viannia）引起的传染病。巴西在巴西东南部。临床表现是巨大的，从无症状到严重的粘膜LeishManiaisis（ml）。已经提出，病原体的变异没有完全解释响应谱和临床表现的可变性。以前的数据表明，宿主遗传学也在疾病结果中发挥作用。在此，我们已经使用案例对照研究设计测试了TNF，IL10，IL12和MIF单核苷酸多态性（SNP）的关联，包括110个皮肤Leishmaniaisis（CL）患者和682名健康受试者。还使用LeishMania抗原评估基因型 - 表型相关性，以刺激从固化的CL患者获得的外周血单核细胞。结果表明，MIF -173C等位基因与LeishManiaisis结果相关，也与培养上清液中的较低水平的MIF相关。此外，在LeishManiaisis患者中，TNF -308AA基因型在统计学上增加。结果表明，MIF -173C载体产生的MIF的较低水平可能影响宿主 - 利什曼蛋白相互作用，有利于感染和疾病进展。另一方面，高TNF水平可以有助于组织损伤，从而导致皮肤病变。

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