...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Blood cytokine, chemokine and growth factor profiling in a cohort of pregnant women from tropical countries
【24h】

Blood cytokine, chemokine and growth factor profiling in a cohort of pregnant women from tropical countries

机译：血细胞因子，趋化因子和热带妇女队列中的增长因子分析来自来自热带国家的孕妇

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The immune status of women changes during and after pregnancy, differs between blood compartments at delivery and is affected by environmental factors particularly in tropical areas endemic for multiple infections. We quantified the plasma concentration of a set of thirty-one T(H)1, T(H)2, T(H)17 and regulatory cytokines, proinflammatory and anti-inflammatory cytokines and chemokines, and growth factors (altogether biomarkers), in a cohort of 540 pregnant women from five malaria-endemic tropical countries. Samples were collected at recruitment (first antenatal visit), delivery (periphery, cord and placenta) and postpartum, allowing a longitudinal analysis. We found the lowest concentration of biomarkers at recruitment and the highest at postpartum, with few exceptions. Among them, IL-6, HGF and TGF-beta had the highest levels at delivery, and even higher concentrations in the placenta compared to peripheral blood. Placental concentrations were generally higher than peripheral, except for eotaxin that was lower. We also compared plasma biomarker concentrations between the tropical cohort and a control group from Spain at delivery, presenting overall higher biomarker levels the tropical cohort, particularly pro-inflammatory cytokines and growth factors. Only IL-6 presented lower levels in the tropical group. Moreover, a principal component analysis of biomarker concentrations at delivery showed that women from Spain grouped more homogenously, and that IL-6 and IL-8 clustered together in the tropical cohort but not in the Spanish one. Plasma cytokine concentrations correlated with Plasmodium antibody levels at postpartum but not during pregnancy. This basal profiling of immune mediators over gestation and in different compartments at delivery is important to subsequently understand response to infections and clinical outcomes in mothers and infants in tropical areas.
机译：妇女的免疫状态在怀孕期间和妊娠后发生变化，交付时的血液隔室之间的不同，并且受到对多种感染的热带地区的环境因素的影响。我们量化了一组三十一（h）1，t（h）2，t（h）17和调节细胞因子，促炎和抗炎细胞因子和趋化因子（共生物标志物）的血浆浓度（完全生物标志物），在来自五个疟疾的孕妇的群组中，来自五个疟疾的热带国家。在募集（第一次产前访问），递送（周围，脐带和胎盘）和产后，允许纵向分析。我们发现招聘中最低的生物标志物和产后最高的生物标志物，少数例外情况下。其中，与外周血相比，IL-6，HGF和TGF-β在递送时具有最高水平，胎盘在胎盘中甚至更高的浓度。胎盘浓度通常高于外周，除了较低的Eotaxin。我们还将热带队列和对照组的血浆生物标志物浓度与西班牙交付中的热带队列和对照组进行比较，呈现整体较高的生物标志物水平热带队列，特别是促炎细胞因子和生长因子。只有IL-6在热带群体中呈现较低的水平。此外，交付中的生物标志物浓度的主要成分分析表明，来自西班牙的女性更加均匀地归类，并且IL-6和IL-8在热带队列中聚集在一起，但不在西班牙语中聚集在一起。血浆细胞因子浓度与产后的疟原虫抗体水平相关，但在妊娠期间没有。这种免疫介质在妊娠和不同隔室中的这种基础剖面对于随后了解热带地区母亲和婴儿的感染和临床结果的重要性是重要的。

著录项

  • 来源
    《Cytokine》 |2020年第2020期|共11页
  • 作者

    Dobano Carlota; Bardaji Azucena; Kochar Swati; Kochar Sanjay K.; Padilla Norma; Lopez Marta; Unger Holger W.; Ome-Kaius Maria; Eugenia Castellanos Maria; Arevalo-Herrera Myriam; Hans Dhiraj; Martinez-Espinosa Flor E.; Botto-Menezes Camila; Malheiros Adriana; Desai Meghna; Casellas Aina; Chitnis Chetan E.; Rogerson Stephen; Mueller Ivo; Menendez Clara; Requena Pilar;

  • 作者单位

    Univ Barcelona Hosp Clin ISGlobal Carrer Rossello 132 E-08036 Barcelona Spain;

    Univ Barcelona Hosp Clin ISGlobal Carrer Rossello 132 E-08036 Barcelona Spain;

    PBM Hosp Med Coll Bikaner 334001 Rajasthan India;

    PBM Hosp Med Coll Bikaner 334001 Rajasthan India;

    Univ Valle Guatemala Ctr Estudios Salud 18 Ave 11-95 Guatemala City 01015 Guatemala;

    CIBER ER IDIBAPS Hosp Clin Dept Maternal Fetal Med Carrer Rossello 149 Barcelona 08036 Spain;

    Papua New Guinea Inst Med Res POB 378 Madang 511 Papua N Guinea;

    Papua New Guinea Inst Med Res POB 378 Madang 511 Papua N Guinea;

    Univ Valle Guatemala Ctr Estudios Salud 18 Ave 11-95 Guatemala City 01015 Guatemala;

    Caucaseco Sci Res Ctr Km 6 Via Cali Puerto Tejada Cali Colombia;

    Jawaharlal Nehru Univ Int Ctr Genet Engn &

    Biotechnol Aruna Asaf Ali Marg Delhi 110067 India;

    Fundacao Med Trop Dr Heitor Vieira Dourado Av Pedro Teixeira S-N BR-69040000 Manaus AM Brazil;

    Fundacao Med Trop Dr Heitor Vieira Dourado Av Pedro Teixeira S-N BR-69040000 Manaus AM Brazil;

    Univ Fed Amazonas Inst Ciencias Biol Av Jauary Marinho Setor Sul Coroado Manaus AM Brazil;

    Ctr Dis Control &

    Prevent Div Parasit Dis &

    Malaria Malaria Branch 1600 Clifton Rd Atlanta GA;

    Univ Barcelona Hosp Clin ISGlobal Carrer Rossello 132 E-08036 Barcelona Spain;

    Jawaharlal Nehru Univ Int Ctr Genet Engn &

    Biotechnol Aruna Asaf Ali Marg Delhi 110067 India;

    Univ Melbourne Parkville Vic 3010 Australia;

    Walter &

    Eliza Hall Inst Med Res 1G Royal Parade Parkville Vic 3052 Australia;

    Univ Barcelona Hosp Clin ISGlobal Carrer Rossello 132 E-08036 Barcelona Spain;

    Univ Barcelona Hosp Clin ISGlobal Carrer Rossello 132 E-08036 Barcelona Spain;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Pregnancy; Tropical country; Placenta; Cord; Malaria; Cytokine; Chemokine; Growth factor;

    机译：怀孕;热带国家;胎盘;脐带;疟疾;细胞因子;趋化因子;生长因子;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号