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MMP-12 and S100s in saliva reflect different aspects of periodontal inflammation

机译：唾液中的MMP-12和S100s反映了牙周炎炎症的不同方面

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Matrix metalloproteinase (MMP)-12, S100A8/A9, and S100Al2 are involved in innate immune responses. We addressed whether different aspects of oral health and non-disease-related covariates influence their levels in saliva. 436 participants were clinically examined, completed a health questionnaire, and provided stimulated saliva. Salivary levels of MMP-12, S100A8/A9, and S100Al2 were determined by enzyme-linked immunosorbent assays. Lower MMP-12 levels were observed in individuals 40-64 years old (yo) compared to 40 yo, and higher S100A8/A9 levels were found in individuals 64 yo compared to 40-64 yo. Smokers exhibited lower MMP-12 and S100Al2 levels compared to non-smokers. All three proteins were elevated in individuals with bleeding on probing (BOP) 20% compared to those with BOP = 20%, and the S100A8/A9 levels were higher in individuals having = 10% gingival pocket depths (PPD) = 4 mm compared to the ones with shallow pockets 4 mm. The extent of alveolar bone loss or presence of manifest caries did not alter any of the markers. MMP-12, S100A8/A9, and S100A12 levels were higher in participants with high periodontal inflammatory burden. All three proteins correlated positively to BOP, PPD, and to several inflammatory mediators. The explanatory variables for MMP-12 in saliva were age, smoking, presence of any tumor, and percentage of PPD 4 mm. The determinant of salivary S100A8/A9 was percentage of BOP, while S100Al2 levels were associated with percentage of BOP and presence of any tumor. Taken together, MMP-12 and the S100/calgranulin levels in saliva reflect different aspects of periodontal inflammation. Smoking and age should be taken into account in further investigation of these proteins as biomarker candidates of periodontal disease.
机译：基质金属蛋白酶（MMP）-12，S100A8 / A9和S100Al2涉及先天免疫应答。我们解决了口腔健康和非疾病相关的协变量的不同方面会影响唾液中的水平。 436名参与者在临床上检查，完成了健康问卷，并提供了刺激的唾液。通过酶联免疫吸附试验确定MMP-12，S100A8 / A9和S100Al2的唾液水平。与＆在个人和GT中发现了40 yo，更高的S100a8 / a9水平; 64 yo相比40-64哟。与非吸烟者相比，吸烟者表现出较低的MMP-12和S100Al2水平。所有三种蛋白质在探测（BOP）＆gt上出血的个体升高。与BOP＆ = 20％相比的20％，并且在＆gt的个体中的单个均匀的S100A8 / A9水平较高。= 10％牙龈口袋深度（PPD）＆ = 4mm，与浅口袋＆LT; 4毫米。肺泡骨质损失或清单龋病的程度没有改变任何标记。高牙周炎炎症负担的参与者中MMP-12，S100A8 / A9和S100A12水平较高。所有三种蛋白质都与BOP，PPD和几种炎症介质相关联。 MMP-12在唾液中的解释性变量是年龄，吸烟，任何肿瘤的存在，并且PPD 4mm的百分比。唾液S100A8 / A9的决定因素是BOP的百分比，而S100Al2水平与BOP的百分比和任何肿瘤的存在相关。唾液中的MMP-12和S100 / Calgranulin水平反映了牙周炎的不同方面。在进一步调查这些蛋白质作为牙周病的生物标志物候选方面，应考虑吸烟和年龄。

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