The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation

Stanciu Adina Elena; Vatasescu Radu Gabriel; Stanciu Marcel Marian; Serdarevic Nafija; Dorobantu Maria

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The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation

机译：亲纤维化生物标志物在阵发性和持续的心房颤动中的作用

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Purpose: Signaling pathways involved in electrical, structural and contractile remodeling processes behind development and progression of atrial fibrillation (AF) have not been completely elucidated, but it seems to be related to complex interactions among neurohormonal and cellular mediators. We aimed to investigate interleukin-6 (IL-6), transforming growth factor-betal (TGF-beta 1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), as biomarkers of atrial remodeling, in patients with paroxysmal and persistent AF, and their correlation with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) and left atrial (LA) diameter.

机译：目的：涉及电气，结构和收缩流程的信号通路和心房颤动的进展（AF）尚未完全阐明，但似乎与神经异常和细胞介质之间的复杂相互作用有关。我们旨在研究白细胞介素-6（IL-6），转化生长因子 - β（TGF-β1），基质金属蛋白酶-9（MMP-9），金属蛋白酶-1（TIMP-1）的组织抑制剂，作为生物标志物患有阵发性和持久性AF的患者的心房重塑及其与脑利钠肽（NT-PROPNP）和左心房（LA）直径的N-末端前骨髓核心的相关性。

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来源
《Cytokine》 |2018年第2018期|共6页
作者
Stanciu Adina Elena; Vatasescu Radu Gabriel; Stanciu Marcel Marian; Serdarevic Nafija; Dorobantu Maria;
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作者单位

Inst Oncol Bucharest Dept Carcinogenesis &

Mol Biol 252 Fundeni Bucharest 022338 Romania;

Clin Emergency Hosp Bucharest Dept Cardiol 8 Calea Floreasca Bucharest 014461 Romania;

Univ Politehn Bucuresti Fac Elect Engn 313 Splaiul Independentei Bucharest 060042 Romania;

Univ Sarajevo Ctr Clin Inst Clin Chem &

Biochem Bolnicka 25 Sarajevo 71000 Bosnia &

Herceg;

Clin Emergency Hosp Bucharest Dept Cardiol 8 Calea Floreasca Bucharest 014461 Romania;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Atrial fibrillation; TGF-beta 1; Matrix metalloproteinase-9: tissue inhibitor of metalloproteinase-1 ratio; NT-proBNP; Left atrial diameter; Atrial remodeling;

机译：心房颤动;TGF-β1;基质金属蛋白酶-9：金属蛋白酶-1的组织抑制剂。NT-probnp;左心房直径;心房重塑;

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1. The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation [J] . Stanciu Adina Elena, Vatasescu Radu Gabriel, Stanciu Marcel Marian, Cytokine . 2018,第期

机译：亲纤维化生物标志物在阵发性和持续的心房颤动中的作用
2. CHA(2)DS(2)-VASc score and blood biomarkers to identify patients with atrial high rate episodes and paroxysmal atrial fibrillation: the role of TIMP-4 regulation [J] . Patane Salvatore, Patane Francesco Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2018,第7期

机译：CHA（2）DS（2）-vasc评分和血液生物标志物鉴定心房高速发作和阵发性心房颤动的患者：TIMP-4调控的作用
3. CHA(2)DS(2)-VASc score and blood biomarkers to identify patients with atrial high rate episodes and paroxysmal atrial fibrillation: the role of TIMP-4 regulation-Authors' reply [J] . Wakula Paulina, Heinzel Frank R. Europace: European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology . 2018,第7期

机译：CHA（2）DS（2）-vasc评分和血液生物标志物鉴定心房高速发作和阵发性心房颤动的患者：TIMP-4规则 - 作者的作用的作用
4. A Straightforward Methodology to Distinguish Complex Fractionated Atrial Electrograms of Paroxysmal from Persistent Atrial Fibrillation [C] . Emanuela Finotti, Edward J Ciaccio, Hasan Garan, E-Health and Bioengineering Conference . 2020

机译：一种直接的方法，以区分复杂的分馏心脏电视图免受持续的心房颤动的阵发性
5. A Meta-Analysis on the Clinical Effectiveness of Cryoballoon Versus Radiofrequency Ablation in Patients With Paroxysmal Atrial Fibrillation [D] . Lam, Kai Kwan Jeff 2019

机译：阵发性心房颤动患者冷冻球囊与射频消融术临床疗效的Meta分析
6. The Role of Pro-Fibrotic Biomarkers in Atrial Fibrillation [O] . Jelena Kornej, Andreas Bollmann 2016

机译：促纤维化生物标志物在心房颤动中的作用
7. The Role of Pro-Fibrotic Biomarkers in Atrial Fibrillation [O] . Jelena Kornej, MD, Andreas Bollmann, MD, PhD 2016

机译：促纤维化生物标志物在心房颤动中的作用

The role of pro-fibrotic biomarkers in paroxysmal and persistent atrial fibrillation

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