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首页> 外文期刊>Cytokine >IL-23/IL-17 immune axis in Guillain Barre Syndrome: Exploring newer vistas for understanding pathobiology and therapeutic implications
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IL-23/IL-17 immune axis in Guillain Barre Syndrome: Exploring newer vistas for understanding pathobiology and therapeutic implications

机译：IL-23 / IL-17 Guillain Barre综合征的免疫轴：探索新的Vistas以了解病理生物学和治疗意义

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Guillain Barre Syndrome (GBS) is a severe disorder of the peripheral nervous system with an inadequately known etiopathology. It is a post infectious immune mediated disorder, characterized by autoantibody production, complement activation as well as T reactivity against gangliosides. However, the precise etiopathogenesis remains poorly understood in a majority of the patients. Th17 cells, a recently identified lineage of Th cells have emerged as a predominant inducer of autoimmunity and inflammation in various immunological disorders. Pathobiological role of Th17 pathway is also becoming increasingly apparent in the nervous system disorders. Two cytokines, such as IL-23, known to determine the pathogenic potential of Th17 cells and IL-17, a prototype effector cytokine of Th17 pathway can form IL-23/IL-17 immune axis. Aberrant functioning of this immune axis has been implicated in many autoimmune diseases. Therapeutic strategies that potentially target this immune axis have shown encouraging results in diseases with immunological underpinnings. Preliminary data obtained both from animal and clinical studies indicate a possible role of this immune axis in GBS. Herein, we explore and highlight the relevance and functional implications of IL-23/IL-17 immune axis in GBS. Understanding this immune axis may shed important insights into the etiology and treatment of GBS.
机译：Guillain Barre综合征（GBS）是周围神经系统的严重疾病，具有令人惊讶的病理学病理学。它是一种后期传染性免疫介导的疾病，其特征在于自身抗体产生，补体激活以及对神经节苷脂的反应性。然而，在大多数患者中，精确的病因发生器仍然是较差的理解。 Th17细胞，最近鉴定的细胞谱系已经出现为各种免疫疾病中的自身免疫和炎症的主要诱导剂。神经系统疾病中，TH17途径的病理学作用也越来越明显。已知用于确定Th17细胞和IL-17的致病潜力的两种细胞因子，Th17途径的原型效应细胞因子可以形成IL-23 / IL-17免疫轴。这种免疫轴的异常功能涉及许多自身免疫性疾病。潜在靶向这种免疫轴的治疗策略表明令人鼓舞的免疫学疾病导致疾病。从动物和临床研究获得的初步数据表明这种免疫轴在GBS中的可能作用。在此，我们探讨并突出IL-23 / IL-17免疫轴在GBS中的相关性和功能影响。了解这种免疫轴可能对GBS的病因和治疗揭示重要的见解。

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