ICAM-1 in HIV infection and underlying mechanisms

Yu Xiaowen; Shang Hong; Jiang Yongjun

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ICAM-1 in HIV infection and underlying mechanisms

机译：艾滋病毒感染和潜在机制的ICAM-1

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Intercellular adhesion molecule 1 (ICAM-1) is a glycoprotein that participates in inflammatory and immune responses. Both cell surface and soluble ICAM-1 are significantly increased during human immunodeficiency virus (HIV) infection, and ICAM-1 has important functions in promoting inflammatory responses and enhancing HIV infectivity; however, a comprehensive summary these roles has yet to be elaborated. In this review we describe the general biological characteristics of ICAM-1, its association with HIV disease progression and promotion of HIV production, mechanisms inducing upregulation of ICAM-1, and possible intervention strategies, representing important insights in the context of HIV treatment.

机译：细胞间粘附分子1（ICAM-1）是参与炎症和免疫应答的糖蛋白。在人类免疫缺陷病毒（HIV）感染期间，ICAM-1的细胞表面和可溶性ICAM-1都显着增加，并且在促进炎症反应和增强HIV感染性方面具有重要作用; 但是，综合摘要尚未详细阐述这些角色。在本综述中，我们描述了ICAM-1的一般生物学特性，其与艾滋病毒疾病进展和促进艾滋病毒疾病的促进，机制诱导ICAM-1的机制，以及可能的干预策略，代表艾滋病毒治疗背景下的重要见解。

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来源
《Cytokine》 |2020年第2020期|共9页
作者
Yu Xiaowen; Shang Hong; Jiang Yongjun;
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作者单位

China Med Univ Affiliated Hosp 1 Dept Lab Med NHC Key Lab AIDS Immunol 155 Nanjing North St;

China Med Univ Affiliated Hosp 1 Dept Lab Med NHC Key Lab AIDS Immunol 155 Nanjing North St;

China Med Univ Affiliated Hosp 1 Dept Lab Med NHC Key Lab AIDS Immunol 155 Nanjing North St;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
ICAM-1; sICAM-1; HIV; Disease progression; Mechanism;

机译：ICAM-1;SICAM-1;艾滋病毒;疾病进展;机制;

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专利

1. ICAM-1 in HIV infection and underlying mechanisms [J] . Yu Xiaowen, Shang Hong, Jiang Yongjun Cytokine . 2020,第期

机译：艾滋病毒感染和潜在机制的ICAM-1
2. Mechanisms underlying abnormalities of immune activation/coagulation in HIV infection [J] . Clifford Lane Journal of the International Aids Society . 2014,第4Suppla3期

机译：HIV感染中免疫激活/凝血异常的潜在机制
3. Transendothelial Migration of Monocytes: The Underlying Molecular Mechanisms and Consequences of HIV-1 Infection [J] . Clare L.V. Maslin Katherine Kedzierska Nicole L. Webster William A. Muller Suzanne M. Crowe Current HIV Research . 2005,第4期

机译：单核细胞的跨内皮迁移：HIV-1感染的潜在分子机制和后果。
4. Systems Biology and Systems Pharmacology Approaches to HIV Infection and TB/HIV Co-Infection [C] . Elsje Pienaar AIChE Annual Meeting . 2016

机译：系统生物学和系统药理学方法艾滋病毒感染和TB / HIV共感染
5. The Influence of Polymicrobial Interactions on Antibiotic Sensitivity: Underlying Mechanisms and Potential Implications for Treating Chronic Infections [D] . Orazi, Giulia. 2019

机译：多发性相互作用对抗生素敏感性的影响：治疗慢性感染的潜在机制和潜在影响
6. Mechanisms underlying abnormalities of immune activation/coagulation in HIV infection [O] . Clifford Lane 2014

机译：HIV感染中免疫激活/凝血异常的潜在机制
7. Mechanisms underlying abnormalities of immune activation/coagulation in HIV infection [O] . Clifford Lane 2014

机译：HIV感染中免疫激活/凝固异常的机制

ICAM-1 in HIV infection and underlying mechanisms

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