...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Cytokines and hs-CRP levels in individuals treated with low-dose aspirin for cardiovascular prevention: A population-based study (CoLaus Study)
【24h】

Cytokines and hs-CRP levels in individuals treated with low-dose aspirin for cardiovascular prevention: A population-based study (CoLaus Study)

机译：用低剂量阿司匹林治疗心血管预防治疗的个体细胞因子和HS-CRP水平：基于人群的研究（CONAUS研究）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Pro-inflammatory cytokines and high-sensitive C-reactive protein (hs-CRP) are associated with increased risk for cardiovascular disease. Low-dose aspirin for CV prevention is reported to have anti-inflammatory effects. The aim of this study was to determine the association between pro-inflammatory cytokines and hs-CRP levels and low-dose aspirin use for cardiovascular prevention in a population-based cohort (CoLaus Study). We assessed blood samples in 6085 participants (3201 women) aged 35-75. years. Medications' use and indications were recorded. Among aspirin users (n=1'034; 17%), overall low-dose users (351; 5.8%) and low-dose for cardiovascular prevention users (324; 5.3%) were selected for analysis. Pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α were assessed by a multiplex particle-based flow cytometric assay and hs-CRP by an immunometric assay. Cytokines and hs-CRP were presented in quartiles. Multivariate analysis adjusting for sex, age, smoking status, body mass index, diabetes mellitus and immunomodulatory drugs showed no association between cytokines and hs-CRP levels and low-dose aspirin use for cardiovascular prevention, either comparing the topmost vs. the three other quartiles (OR 95% CI, 0.84 (0.59-1.18), 1.03 (0.78-1.32), 1.10 (0.83-1.46), 1.00 (0.67-1.69) for IL-1β, IL-6, TNF-α and hs-CRP, respectively), or comparing the topmost quartile vs. the first one (OR 95% CI, 0.87 (0.60-1.26), 1.19 (0.79-1.79), 1.26 (0.86-1.84), 1.06 (0.67-1.69)). Low-dose aspirin use for cardiovascular prevention does not impact plasma pro-inflammatory cytokine and hs-CRP levels in a population-based cohort.
机译：促炎细胞因子和高敏感的C反应蛋白（HS-CRP）与心血管疾病的风险增加有关。据报道，用于CV预防的低剂量阿司匹林具有抗炎作用。本研究的目的是确定促炎细胞因子和HS-CRP水平和低剂量阿司匹林在基于人群的队列（CONAUS研究）中的心血管预防的低剂量阿司匹林。我们评估了35-75岁的6085名参与者（3201名女性）的血液样本。年。记录了药物的使用和适应症。在阿司匹林用户（n = 1'034; 17％）中，整体低剂量用户（351; 5.8％）和用于心血管预防用户的低剂量（324; 5.3％）进行分析。通过免疫测定法评估促炎细胞因子（IL-1β，IL-6和TNF-α。细胞因子和HS-CRP以四分位数呈现。多变量分析调整性别，年龄，吸烟状态，体重指数，糖尿病和免疫调节药物在细胞因子和HS-CRP水平之间没有关联，低剂量阿司匹林用于心血管预防，比较最多的与其他四分位数（或95％） CI，0.84（0.59-1.18），1.03（0.78-1.32），1.10（0.83-1.46），IL-1β，IL-6，TNF-α和HS-CRP分别为1.00（0.67-1.69），或比较最多的四分位数与第一个（或95％CI，0.87（0.60-1.26），1.19（0.79-1.79），1.26（0.86-1.84），1.06（0.67-1.69））。低剂量阿司匹林用于心血管预防不会影响基于人群的群组中的血浆促炎细胞因子和HS-CRP水平。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号