Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis

Gadisa Endalamaw; Tasew Geremew; Abera Adugna; Gelaye Woyneshet; Chanyalew Menberework; Abebe Markos; Laskay Tamas; Aseffa Abraham

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Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis

机译：在埃塞俄比亚内脏利山病成功治疗后临床治疗后的血清签名

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Background: In Ethiopia, visceral leishmaniasis (VL) is a growing public health threat. Among the key challenges in VL control in Ethiopia is lack of an effective test of cure. The recommended test of cure is parasite detection. As sterile cure is not expected with the current widely used drugs, the value of parasite detection as test of cure is questionable. Moreover, the sampling is invasive, requires a well-equipped facility and highly skilled personnel, which are all hardly found in endemic set-ups.

机译：背景：在埃塞俄比亚，内脏Leishmaniaisis（VL）是一个不断增长的公共卫生威胁。在埃塞俄比亚的VL控制中的关键挑战缺乏对治愈的有效测试。建议的固化试验是寄生虫检测。由于目前的广泛使用的药物预计不预期无菌固化，寄生虫检测的价值是可疑的。此外，采样是侵入性的，需要一个装备精良的设施和高技能人员，这一切都几乎没有发现在地方性设置中。

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来源
《Cytokine》 |2017年第2017期|共4页
作者
Gadisa Endalamaw; Tasew Geremew; Abera Adugna; Gelaye Woyneshet; Chanyalew Menberework; Abebe Markos; Laskay Tamas; Aseffa Abraham;
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作者单位

Armauer Hansen Res Inst POB 1005 Jimma Rd Addis Ababa Ethiopia;

Armauer Hansen Res Inst POB 1005 Jimma Rd Addis Ababa Ethiopia;

Armauer Hansen Res Inst POB 1005 Jimma Rd Addis Ababa Ethiopia;

Amhara Reg State Referral &

Res Lab Bahir Dar Ethiopia;

Armauer Hansen Res Inst POB 1005 Jimma Rd Addis Ababa Ethiopia;

Armauer Hansen Res Inst POB 1005 Jimma Rd Addis Ababa Ethiopia;

Univ Lubeck Lubeck Germany;

Armauer Hansen Res Inst POB 1005 Jimma Rd Addis Ababa Ethiopia;

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原文格式 PDF
正文语种 eng
中图分类细胞生物学;
关键词
Signature biomarker; Visceral leishmaniasis treatment; Soluble CD40 ligand; Matrix metalloproteinase nine; Interleukin ten;

机译：签名生物标志物;内脏LeishManiaisis治疗;可溶性CD40配体;基质金属蛋白酶九;白细胞介素十;

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1. Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis [J] . Gadisa Endalamaw, Tasew Geremew, Abera Adugna, Cytokine . 2017,第期

机译：在埃塞俄比亚内脏利山病成功治疗后临床治疗后的血清签名
2. A Comparison of Miltefosine and Sodium Stibogluconate for Treatment of Visceral Leishmaniasis in an Ethiopian Population with High Prevalence of HIV Infection [J] . Koert Ritmeijer, Abren Dejenie, Yibeltal Assefa, Clinical Infectious Diseases . 2006,第3期

机译：Miltefosine和Stibogluconate钠在高感染HIV的埃塞俄比亚人群中治疗内脏利什曼病的比较
3. A prospective randomized, comparative, open-label trial of the safety and efficacy of paromomycin (aminosidine) plus sodium stibogluconate versus sodium stibogluconate alone for the treatment of visceral leishmaniasis. [J] . Thakur CP, Kanyok TP, Pandey AK, Transactions of the Royal Society of Tropical Medicine and Hygiene . 2000,第4期

机译：帕罗霉素（氨基嘧啶）加司他葡糖酸钠与单独司他葡糖酸钠治疗内脏利什曼病的安全性和有效性的前瞻性随机对照开放性试验。
4. Development of an Amphotericin B- Poly(methacrylic acid) based treatment for Visceral Leishmaniasis [C] . K.A. Les, A. Godwin, J. Choi, Annual meeting exposition of the Controlled Release Society . 2010

机译：基于两性霉素B-聚（甲基丙烯酸）内脏利什曼病的治疗方法的开发
5. Visceral leishmaniasis in urban areas: The issue of cross reactivity among serological tests [D] . Jeronimo, Selma M. B. 2015

机译：城市地区的内脏Leishmaniaisis：血清学检测中交叉反应性的问题
6. The Cured Immune Phenotype Achieved by Treatment of Visceral Leishmaniasis in the BALB/c Mouse with a Nonionic Surfactant Vesicular Formulation of Sodium Stibogluconate Does Not Protect against Reinfection [O] . K. C. Carter, A. J. Baillie, A. B. Mullen 1999

机译：通过非离子表面活性剂囊肿性葡糖酸钠的治疗BALB / c小鼠内脏利什曼病的治愈的免疫表型不能防止再感染
7. The Cured Immune Phenotype Achieved by Treatment of Visceral Leishmaniasis in the BALB/c Mouse with a Nonionic Surfactant Vesicular Formulation of Sodium Stibogluconate Does Not Protect against Reinfection [O] . K. C. Carter, A. J. Baillie, A. B. Mullen 1999

机译：通过在BALB / C小鼠中处理具有非离子表面活性剂的钠葡萄糖酸钠的非离子表面活性剂凹凸制剂而实现的固化免疫表型并不能防止重新感染
8. Electron Microscopy of Leishmania donovani in Splenic Aspirates from Patients with Visceral Leishmaniasis during Treatment with Sodium Stibogluconate [R] . Chulay, J. D., Fawcett, D. W., Chunge, C. N. 1985

机译：杜氏葡萄糖酸钠治疗内脏利什曼病患者脾脏抽吸物中杜氏利什曼原虫的电子显微镜观察

Serological signatures of clinical cure following successful treatment with sodium stibogluconate in Ethiopian visceral leishmaniasis

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