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首页> 外文期刊>Cytokine >Tumor-derived cytokines impair myogenesis and alter the skeletal muscle immune microenvironment
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Tumor-derived cytokines impair myogenesis and alter the skeletal muscle immune microenvironment

机译：肿瘤衍生的细胞因子损害肌瘤生殖，改变骨骼肌免疫微环境

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摘要

Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an incomplete understanding of the role of tumor-derived factors in muscle wasting and sparse knowledge of how these factors impact in vivo muscle regeneration. Here, we identify several cytokines/chemokines that negatively impact in vitro myogenic differentiation. We show that one of these cytokines, CXCL1, potently antagonizes in vivo muscle regeneration and interferes with in vivo muscle satellite cell homeostasis. Strikingly, CXCL1 triggers a robust and specific neutrophil/M2 macrophage response that likely underlies or exacerbates muscle repair/regeneration defects. Taken together, these data highlight the pleiotropic nature of a novel tumor-derived cytokine and underscore the importance of cytokines in muscle progenitor cell regulation.
机译：肌肉浪费是骨骼肌肿块和功能的下降，其与老化，肥胖症和包括癌症在内的病理学的谱相关。癌症相关的浪费不仅可以降低生命的质量，而且直接影响癌症死亡率，化学治疗疗效和外科检查。对肿瘤衍生因子在肌肉浪费和稀疏了解这些因素在体内肌肉再生中的影响。在这里，我们鉴定了几种细胞因子/趋化因子，这些细胞因子/趋化因子对体外源性分化产生负面影响。我们展示了这些细胞因子，CXCL1中的一种，效果拮抗体内肌肉再生并干扰体内肌肉卫星细胞稳态。引人注目的是，CXCL1触发了可能是肌肉修复/再生缺陷的稳健和特异性的中性粒细胞/ M2巨噬细胞反应。总之，这些数据突出了一种新型肿瘤衍生的细胞因子的抗热性本性，并强调了细胞因子在肌祖细胞调节中的重要性。

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  • 来源
    《Cytokine》 |2018年第2018期|共9页
  • 作者

    Hogan Kelly A.; Cho Dong Seong; Arneson Paige C.; Samani Adrienne; Palines Patrick; Yang Yanan; Doles Jason D.;

  • 作者单位

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

    Mayo Clin Dept Biochem &

    Mol Biol 200 First St SW Guggenheim 16-11A1 Rochester MN 55905 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Lung cancer; Satellite cells; Myogenesis; Regeneration; Immune cells; Cytokines;

    机译：肺癌;卫星细胞;肌钙生成;再生;免疫细胞;细胞因子;

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