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首页> 外文期刊>Cytokine >Increased frequency of CCR7 + CD4 + T cells from patients with primary Sj?gren's syndrome: An indicator of disease activity rather than of damage severity
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Increased frequency of CCR7 + CD4 + T cells from patients with primary Sj?gren's syndrome: An indicator of disease activity rather than of damage severity

机译：来自初级SJ的患者的CCR7 + CD4 + T细胞的频率增加？GREN的综合征：疾病活动的指标而不是伤害严重程度

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摘要

Expression of CCR7 on T cells has been reported to be associated with the lymphocytic migration and infiltration, which is recognized as a vital part of the pathogenesis of Primary Sj?gren's syndrome (pSS). Here, we compared the expression of CCR7 on CD4+T cells between pSS patients and control groups, including healthy donors (HD) and patients with systemic lupus erythematosus (SLE) and examined correlations with disease activity and damage severity, which were evaluated by EULAR Sj?gren's Syndrome Disease Activity Index (ESSDAI) and Sjogren's Syndrome Disease Damage Index (SSDDI), respectively. Peripheral blood mononuclear Cells (PBMC) were obtained from patients and controls and expressions of CCR7 were evaluated by flow cytometry. CCR7 was selectively and frequently expressed on CD4+T cells, but less on CD8+T cells of patients with pSS. In contrast, this phenomenon was neither seen in normal subjects nor in patients with SLE. The expression level of CCR7 in the peripheral blood CD4+T cells is closely correlated with ESSDAI, but not SSDDI. Correspondently, the chemotactic index (CI) of CD4+T cells was higher than CD8+T cells in patients with pSS. Furthermore, the CI of CD4+T cells is also higher than that of other controls, which is correlated with ESSDAI. All the findings suggested that CCR7 might play an important role in the development of pSS by mediating the migration of CD4+cells. Thus, the expression of CCR7 in CD4+T cells is probably a useful biomarker to evaluate and monitor disease activity. CCR7 can also potentially be a novel target for the therapy of pSS.
机译：据报道，CCR7对T细胞的表达与淋巴细胞迁移和浸润有关，其被认为是初级SJ的发病机制的重要组成部分（PSS）。在这里，我们将CCR7对PSS患者和对照组之间CD4 + T细胞的表达进行了比较，包括健康供体（HD）和系统性红斑狼疮（SLE）的患者，并通过欧特评估的与疾病活动和伤害严重程度进行了检查的相关性SJ？GREN的综合征疾病活动指数（essdai）和Sjogren分别的综合征疾病损伤指数（SSDDI）。从患者获得外周血单核细胞（PBMC），通过流式细胞术评估CCR7的对照和CCR7的表达。 CCR7选择性并经常在CD4 + T细胞上表达，但在PSS患者的CD8 + T细胞上少表达。相比之下，这种现象既不在正常受试者中都观察到SLE的患者。外周血CD4 + T细胞中CCR7的表达水平与Essdai密切相关，但不是SSDDI。相应地，CD4 + T细胞的趋化指数（CI）高于PSS患者的CD8 + T细胞。此外，CD4 + T细胞的CI也高于其他对照的CI，其与Essdai相关。所有研究结果表明，CCR7通过介导CD4 +细胞的迁移，CCR7可能在PSS的发展中发挥重要作用。因此，CCR7在CD4 + T细胞中的表达可能是评估和监测疾病活性的有用生物标志物。 CCR7还可以是PSS治疗的新靶。

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  • 来源
    《Cytokine》 |2018年第2018期|共9页
  • 作者

    Chunling Wu; Pingting Yang; Haina Liu; Weiguo Xiao; Lijuan Zhao;

  • 作者单位

    Department of Rhematology and Immunology The First Hospital of China Medical University;

    Department of Rhematology and Immunology The First Hospital of China Medical University;

    Department of Rhematology and Immunology The First Hospital of China Medical University;

    Department of Rhematology and Immunology The First Hospital of China Medical University;

    Department of Rhematology and Immunology The First Hospital of China Medical University;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Primary Sj?gren's syndrome; CCR7; Disease activity; Damage severity;

    机译：初级SJ？GREN的综合征;CCR7;疾病活动;伤害严重程度;

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