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An update on the association between metabolic syndrome and osteoarthritis and on the potential role of leptin in osteoarthritis

机译：代谢综合征与骨关节炎与瘦素在骨关节炎中的潜在作用的更新

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Metabolic syndrome (MetS) has been associated with osteoarthritis (OA). Leptin, which is one of the markers of MetS, has been associated with OA pathophysiology. This study aimed to provide an update on the association between MetS and OA and on the potential role of leptin in OA. In this review, we summarized the current knowledge of the association between MetS and OA and updated the evidence on the potential role of leptin in OA. Clinical studies have investigated the epidemiologic association between MetS or its components and OA. Results suggested strong epidemiologic associations between MetS and OA, especially in the Asian population. Animal studies also indicated that metabolic dysregulation may lead to OA pathogenesis. The systemic role of MetS in OA pathophysiology is associated with obesity-related inflammation, the beneficial role of n-3 polyunsaturated fatty acids and deleterious role of cholesterol, physical inactivity, hypertension-induced subchondral ischemia, dyslipidemia-induced ectopic lipid deposition in chondrocytes, hyperglycemia-induced local effects of oxidative stress and advanced glycation end-products, low-grade systemic inflammation, and obesity-related adipokines by inducing the expression of proinflammtory factors. Leptin levels in serum/plasma and synovial fluid were associated with joint pain, radiographic progression, bone formation biomarkers, cartilage volume, knee OA incidence, and total joint arthroplasty in OA patients. Elevated leptin expression and increased effect of leptin on infrapatellar fat pad, synovium, articular cartilage, and bone were also involved in the pathogenesis of OA. Current knowledge indicates a convincing epidemiologic association between MetS and OA, especially in the Asian population. Animal studies have also shown that metabolic dysregulation may lead to OA pathogenesis. Accumulating evidence suggests that leptin may play a potential role in OA pathogenesis. Therefore, leptin and its receptor may be an emerging target for intervention in metabolic-associated OA.
机译：代谢综合征（METS）已与骨关节炎（OA）有关。 Leptin是Mets的标志物之一，已经与OA病理生理学相关。本研究旨在提供关于Mets和OA之间的关联以及瘦素在OA之间的潜在作用的更新。在这篇综述中，我们总结了当前关于METS和OA之间的关联的知识，并更新了关于瘦素在OA中的潜在作用的证据。临床研究研究了Mets或其组分和OA之间的流行病学关联。结果建议大都会和OA之间的强大流行病学协会，特别是在亚洲人口中。动物研究还表明代谢失调可能导致OA发病机制。 OA病理生理学中Mets的全身作用与肥胖相关的炎症有关，N-3多不饱和脂肪酸的有益作用和胆固醇的有害作用，物理不活跃，高血压诱导的骨髓性缺血，血脂血症诱导的软骨细胞中的异位脂质沉积，通过诱导促果实因子的表达，高血糖血症诱导的氧化应激和先进的糖化末端产物，低级全身炎症和肥胖相关的adipokines。血清/血浆和滑液中的瘦素水平与关节疼痛，放射线进展，骨形成生物标志物，软骨体积，膝关节OA发病率和OA患者的总关节置换术相关。瘦素表达和瘦素对丙蛋白脂肪垫，滑素，关节软骨和骨骼的增加也参与了OA的发病机制。目前的知识表明了Mets和OA之间的令人信服的流行病学关联，特别是在亚洲人口中。动物研究还表明，代谢失调可能导致OA发病机制。积累证据表明，瘦素可能在OA发病机制中发挥潜在作用。因此，瘦素及其受体可以是用于介入代谢相关的OA的新出现靶标。

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