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STAT3 isoforms: Alternative fates in cancer?

机译：STAT3同种型：癌症中的替代性命名？

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摘要

Signal transducer and activator of transcription (STAT) 3 is the main mediator of IL-6-type cytokine signaling and an important transcriptional regulator of cell proliferation, maturation and survival. It has been described as a key player in cancer development and progression. However, under certain circumstances, STAT3 is also considered a potent tumor suppressor. This heterogeneity partially depends on its expression as different isoforms. Alternative splicing gives rise to two STAT3 isoforms, STAT3α and its truncated version STAT3β Both isoforms are transcriptionally active and display distinct functions under physiological and pathological conditions. In fact, while STAT3α is widely described as an oncogene, STAT3β has gained attention as a potential tumor suppressor. This review provides a concise overview of the current knowledge on STAT3 during tumor-igenesis, with special emphasis on the unique and complex roles of its alternatively spliced isoforms.
机译：信号传感器和转录激活剂（统计数据）3是IL-6型细胞因子信号传导的主要介体和细胞增殖，成熟和存活的重要转录调节剂。 它被描述为癌症发展和进展的关键球员。 然而，在某些情况下，STAT3也被认为是有效的肿瘤抑制因子。 这种异质性部分取决于其表达为不同的同种型。 替代剪接产生了两个STAT3同种型，STAT3α及其截短的版本STAT3β两种同种型在生理和病理条件下进行了不同的功能。 实际上，虽然STAT3α被广泛描述为癌基因，但STAT3β作为潜在的肿瘤抑制剂进行了关注。 本次审查简要概述了肿瘤 - Inganish中的Dat3上目前的知识，特别强调其可换切同种型的独特和复杂的角色。

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