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Antimicrobial and proinflammatory effects of two vipericidins

机译：两种Vipericidins的抗菌和促炎效果

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Hospital infections allied to bacterial resistance to antibiotics have become a major worldwide problem. In this context, antimicrobial peptides (AMPs) are presented as an alternative in the control of these resistant organisms. Besides antimicrobial effects, these molecules play a crucial role in immunity by acting as immunomodulators. These peptides can activate inflammatory cells to produce pro- and anti-inflammatory mediators. In this study we will show the activity against multi-drug resistant bacteria (MDRB) of two cathelicidins from South American pit vipers Bothrops atrox and Crotalus durissus temficus, named batroxicidin and crotalicidin. It was observed that both peptides showed activity against MDRB and presented no hemolytic or cytotoxic activity. In addition, the ability of peptides to modulate the production of cytokines TNF-alpha, IL-10 and IL-6 was analyzed using Raw 264.7 cells in the presence of IFN-gamma stimuli, and multi-resistant E. colt and K. pneumoniae antigens. An up-expression or down-expression of TNF-alpha, as well as the IL-10 mediator, was observed. The cytokine IL-6, on the other hand, presented only a down-regulation for Raw 264.7 cell groups. In conclusion, the results demonstrate that both peptides presented a predominantly proinflammatory characteristic to the inflammatory mediators dosed. Overall, even presenting a proinflammatory characteristic, these peptides are still promising for future research and development of new potential antimicrobial molecules.
机译：医院感染与抗生素的细菌抗性均已成为全球主要问题。在这种情况下，抗微生物肽（AMPS）作为控制这些抗性生物的替代方案。除了抗微生物效应，这些分子通过作为免疫调节剂而发挥免疫力的关键作用。这些肽可以激活炎性细胞以产生促炎和抗炎介质。在这项研究中，我们将向南美洲坑VIPERSBLOBSTROX和CROTALUS DURISSUS Temfus的两种水教蛋白的多毒性细菌（MDRB）的活动展示了对南美洲坑毒蕈的多毒性细菌（MDRB），名为Batroisticin和Crotalicinin。观察到两种肽对MDRB的活性显示出并呈现出溶血或细胞毒性活性。此外，在IFN-Gamma刺激的存在下使用Raw 264.7细胞和多抗性大肠杆菌和K.Pneumoniae使用Raw 264.7细胞分析肽调节细胞因子TNF-α，IL-10和IL-6的产生的能力抗原。观察到TNF-α的上表达或下表达，以及IL-10介体。另一方面，细胞因子IL-6仅向原始264.7细胞组呈现下调。总之，结果表明，两种肽都呈现给炎症介质给药的主要炎症特征。总的来说，即使呈现促炎特征，这些肽仍然希望未来的未来研究和开发新的潜在抗微生物分子。

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