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首页> 外文期刊>Cytokine >Cytokine profiles in acute myeloid leukemia patients at diagnosis: Survival is inversely correlated with IL-6 and directly correlated with IL-10 levels
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Cytokine profiles in acute myeloid leukemia patients at diagnosis: Survival is inversely correlated with IL-6 and directly correlated with IL-10 levels

机译：在诊断中急性髓性白血病患者的细胞因子谱：存活与IL-6相反，直接与IL-10水平相关

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摘要

Background: Several evidences support the existence of cytokine deregulation in acute myeloid leukemia (AML) patients that may be associated with pathogenesis, disease progression and patient survival. Methods: In the present study, we analyzed plasma levels of pro- and anti-inflammatory cytokines in AML patients and age-matched healthy donors. TNF-??, IL-6, IL-1??, IL-2, IFN-??, IL-17A, IL-12p70, IL-8, IL-10, IL-4 and IL-5 were analyzed using fluorescent bead-based technology and TGF-?? by ELISA technique. Because age-associated differences in cytokine profiles have been described, patients and healthy individuals were divided into two age groups: up to 65. years and over 65. years. Results: Our results showed that plasma TNF-??, IL-6 and IL-10 levels were higher in AML patients from both groups of age. IL-8 was increased in AML patients less than 65. years while the plasma concentrations of IL-4, IL-5 and IL-12p70 were significantly higher only in elderly AML patients compared with aged-matched healthy controls. Moreover, plasma levels of IL-6 and IL-10 were associated with patient survival and event-free survival. Conclusions: An aberrant production of the pro-inflammatory cytokines IL-6 and TNF-?? and the anti-inflammatory cytokine IL-10 is observed in AML patients. Low levels of IL-6 and high levels of IL-10 represent favorable prognostic factors for survival in AML patients. These results support the idea that cytokine deregulation may be useful as a marker for predicting clinical evolution in AML patients. ? 2013 Elsevier Ltd.
机译：背景：若干证据支持可能与发病机制，疾病进展和患者存活相关的急性髓性白血病（AML）患者中细胞因子放松管制的存在。方法：在本研究中，我们分析了AML患者和年龄匹配的健康供体中的血浆和抗炎细胞因子的血浆水平。使用荧光珠的技术和TGF-??通过ELISA技术。由于已经描述了细胞因子谱的年龄相关的差异，患者和健康个体分为两龄龄群：多达65岁以上65岁。结果：我们的研究结果表明，来自两年龄段的AML患者的血浆TNF - ??，IL-6和IL-10水平较高。 IL-8在少于655岁的AML患者中增加。虽然IL-4，IL-5和IL-12P70的血浆浓度只有在老年AML患者中显着高，而与年龄匹配的健康对照相比。此外，IL-6和IL-10的血浆水平与患者存活和无事项存活相关。结论：促炎细胞因子IL-6和TNF-的异常生产在AML患者中观察到抗炎细胞因子IL-10。低水平的IL-6和高水平的IL-10代表了AML患者存活的良好预后因素。这些结果支持细胞因子放松剂量可用作预测AML患者临床演进的标志物。还2013年elestvier有限公司

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  • 来源
    《Cytokine》 |2013年第3期|共7页
  • 作者

    Sanchez-CorreaB.; BerguaJ.M.; CamposC.; GayosoI.; ArcosM.J.; Ba帽asH.; MorgadoS.; CasadoJ.G.; SolanaR.; TarazonaR.;

  • 作者单位

    Immunology Unit Department of Physiology University of Extremadura 10003 Caceres Spain;

    Department of Hematology Hospital San Pedro de Alcantara Caceres Spain;

    Immunology Unit Instituto Maimonides para la Investigacion Biomedica de Cordoba (IMIBIC);

    Immunology Unit Instituto Maimonides para la Investigacion Biomedica de Cordoba (IMIBIC);

    Department of Hematology Hospital San Pedro de Alcantara Caceres Spain;

    Department of Hematology Hospital San Pedro de Alcantara Caceres Spain;

    Immunology Unit Department of Physiology University of Extremadura 10003 Caceres Spain;

    Immunology Unit Department of Physiology University of Extremadura 10003 Caceres Spain Stem;

    Immunology Unit Instituto Maimonides para la Investigacion Biomedica de Cordoba (IMIBIC);

    Immunology Unit Department of Physiology University of Extremadura 10003 Caceres Spain;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 细胞生物学;
  • 关键词

    Acute myeloid Leukemia; IL-10; IL-6; Pro-inflammatory cytokines; Survival;

    机译：急性髓性白血病;IL-10;IL-6;促炎细胞因子;生存;

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