• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cytokine >Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune-endocrine mediators
【24h】

Evidence that changes in antimicrobial peptides during tuberculosis are related to disease severity, clinical presentation, specific therapy and levels of immune-endocrine mediators

机译：结核期间抗微生物肽的变化有关疾病严重程度，临床介绍，特异性治疗和免疫内分泌介质水平有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Given the role of host defense peptides (HDPs) in the defensive response against mycobacteria, we analyzed the circulating levels of LL-37, beta-defensin-2 and -3 in newly diagnosed patients with pulmonary (PTB) or pleural tuberculosis (PLTB) in whom measurements of pleural fluids were also performed. Severe PTB patients displayed higher circulating amounts of beta-defensin-3, statistically different from controls, further decreasing upon antimycobacterial treatment. LL-37 concentrations appeared within the normal range at diagnosis, but tended to increase during treatment, becoming statistically upon its completion in moderate cases. PLTB patients revealed decreased levels of beta-defensin-2 in presence of increased amounts of beta-defensin-3 and LL-37; in their plasma or pleural fluids. Considering the immune-endocrine dysregulation of tuberculosis, we also performed correlation analysis detecting positive associations between levels of cortisol, IL-6 and beta-defensin-3 in plasma from untreated severe patients as did their dehydroepiandrosterone and LL-37 values. Increased presence of beta-defensins, may represent an attempt to improve defensive mechanisms; which also take part in the inflammatory reaction accompanying TB, reinforced by the association with immune-endocrine mediators. The divergent profile of PLTB patients, decreased beta-defensin-2 but increased beta-defensin-3 and LL-37 levels, suggests a differential role of these HDPs in a situation characterized for its better protective response.
机译：鉴于宿主防毒肽（HDP）在针对分枝杆菌的防御性反应中的作用，我们分析了新诊断患者肺（PTB）或胸膜肺结核患者（PLTB）的LL-37，β-DECENSIN-2和-3的循环水平还进行了胸腔流体的测量。严重的PTB患者显示出更高的循环量的β-防御蛋白-3，统计学不同的对照，进一步降低抗菌药物治疗。 LL-37浓度在诊断的正常范围内出现，但在治疗过程中倾向于增加，统计学变得在中等病例中完成。 PLTB患者在β-防御素-3和LL-37的增加情况下显示出β-DECENSIN-2水平降低;在它们的等离子体或胸膜液中。考虑到结核病的免疫内分泌失调，我们还对来自未处理严重患者的血浆中皮质醇，IL-6和β-防御蛋白-3水平之间的阳性关联进行了相关性分析，其脱氢患者和LL-37值。增加了β-防御素的存在，可以代表改善防御机制的尝试;其中还参与伴随结核病的炎症反应，通过与免疫内分泌介质的关系加固。 PLTB患者的分歧型材降低，β-防御素-2增加但增加了β-防御素-3和LL-37水平，表明这些HDP在表现出更好的保护性反应的情况下的差异作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号